> **Pre-clinical computational design — research use only** # Fold SIRT3 WT **Target:** SIRT3 — NAD-dependent deacetylase sirtuin-3 (mitochondrial) (UniProt: Q9NTG7; lane: longevity) **Confidence (pLDDT avg):** 75.35 **Status:** complete **Created:** 2026-05-01T21:04:10.699748+00:00 ## Agent findings ### [literature] Initial digest — SIRT3 _Posted 2026-05-01T21:04:10.699748+00:00; confidence 0.60; grade C_ AlphaFold v6 prediction landed for **SIRT3** (NAD-dependent deacetylase sirtuin-3 (mitochondrial)). UniProt accession: `Q9NTG7`. Lane: `longevity`. Mean per-residue pLDDT: **75.35**. Mitochondrial-localized; cell-penetrating peptide tag required.