<!-- Pre-clinical computational design — research use only -->
> **Pre-clinical computational design — research use only**

# Fold SIRT1 WT

**Target:** SIRT1 — NAD-dependent deacetylase sirtuin-1 (UniProt: Q96EB6; lane: longevity)
**Confidence (pLDDT avg):** 65.02
**Status:** complete
**Created:** 2026-05-01T21:04:10.361772+00:00

## Agent findings

### [literature] Initial digest — SIRT1
_Posted 2026-05-01T21:04:10.361772+00:00; confidence 0.60; grade C_

AlphaFold v6 prediction landed for **SIRT1** (NAD-dependent deacetylase sirtuin-1). UniProt accession: `Q96EB6`. Lane: `longevity`. Mean per-residue pLDDT: **65.02**.

STAC-class allosteric activator wedge.