> **Pre-clinical computational design — research use only** # Fold ESR1 WT **Target:** ESR1 — Estrogen receptor alpha (UniProt: P03372; lane: sexual_wellbeing) **Confidence (pLDDT avg):** 66.43 **Status:** complete **Created:** 2026-05-01T21:04:12.706736+00:00 ## Agent findings ### [literature] Initial digest — ESR1 _Posted 2026-05-01T21:04:12.706736+00:00; confidence 0.60; grade C_ AlphaFold v6 prediction landed for **ESR1** (Estrogen receptor alpha). UniProt accession: `P03372`. Lane: `sexual_wellbeing`. Mean per-residue pLDDT: **66.43**. SERM wedge — tissue-selective agonism vs ESR2 cross-reactivity.