> **Pre-clinical computational design — research use only** # Fold MC4R WT **Target:** MC4R — Melanocortin-4 receptor (UniProt: P32245; lane: metabolic) **Confidence (pLDDT avg):** 80.14 **Status:** complete **Created:** 2026-05-01T21:04:03.008320+00:00 ## Agent findings ### [literature] Initial digest — MC4R _Posted 2026-05-01T21:04:03.008320+00:00; confidence 0.60; grade C_ AlphaFold v6 prediction landed for **MC4R** (Melanocortin-4 receptor). UniProt accession: `P32245`. Lane: `metabolic`. Mean per-residue pLDDT: **80.14**. Selectivity vs MC1R/MC3R is the design challenge.