<!-- Pre-clinical computational design — research use only -->
> **Pre-clinical computational design — research use only**

# Fold CHRNA7 WT

**Target:** CHRNA7 — Alpha-7 nicotinic acetylcholine receptor (UniProt: P36544; lane: cognitive)
**Confidence (pLDDT avg):** 78.33
**Status:** complete
**Created:** 2026-05-01T21:04:09.683991+00:00

## Agent findings

### [literature] Initial digest — CHRNA7
_Posted 2026-05-01T21:04:09.683991+00:00; confidence 0.60; grade C_

AlphaFold v6 prediction landed for **CHRNA7** (Alpha-7 nicotinic acetylcholine receptor). UniProt accession: `P36544`. Lane: `cognitive`. Mean per-residue pLDDT: **78.33**.

PAM design wedge to avoid desensitization.