HCRTR2

Orexin receptor type 2 / UniProt O43614

Fold Report v1

Model confidence, target context, and design-readiness state.

This page binds the structure viewer to AlphaFold confidence data, agent findings, redacted candidate state, and non-clinical evidence limits so every fold is inspectable before it moves into a dossier.

Structure: alphafold-cdn pLDDT: alphafold db Coverage: 100.0% PAE: AlphaFold DB Candidates: 0 Findings: 1

Mean pLDDT 78.96 Confident backbone model

Residues 444 per-residue parsed

Coverage 100.0% 444/444 residues

Evidence refs 1 agent-linked items

01 / Structure

AlphaFold v6 / streamed through the structure proxy / drag to rotate / scroll to zoom

02 / Per-residue confidence

444 residues - very high (>90) confident (70-90) low (50-70) very low (<50)

03 / AlphaFold metrics

Reference prediction from the AlphaFold Protein Structure Database: predicted aligned error (PAE) plus per-position model confidence.

Predicted aligned error

Blue regions imply stronger relative-position confidence. Red off-diagonal regions signal domain-orientation uncertainty.

Predicted lDDT per position

444 residues / mean 78.96 / min 32.28 / max 98.69

Very high 52.0% 231 residues / >=90

Confident 16.7% 74 residues / 70-89

Low 14.9% 66 residues / 50-69

Very low 16.4% 73 residues / <50

Coverage

Near-complete coverage: 444 observed of 444 residues.

Low-confidence intervals

res 384-444 / mean 49.88 res 1-34 / mean 41.73 res 253-286 / mean 50.91 res 197-206 / mean 57.07

UniProt O43614 / open in AlphaFold DB

04 / Target context

Biological lane

sleep circadian

Family

GPCR_class_A

Pocket modes

ortho

Indication tags

sleep_onset, narcolepsy

Functional sites

Functional-site annotations are not cached for this target yet.

Binding partners

Binding-partner context is not cached for this target yet.

Gene ontology

GO terms are not cached for this target yet.

Residue-level functional sites, binding partners, and ontology tags are ready for ingestion but not cached for this fold yet.

Fold stats

Gene	HCRTR2
Length	444 aa
pLDDT mean	78.96
Confidence	78.96%
pLDDT source	alphafold db
Model state	Confident backbone model
Status	complete
Lane	sleep circadian

Research-use only. Structure confidence is not biological validation; it is a model-quality receipt for downstream evidence grading.

Markdown export Proof spine Learning loop

Proof spine

This fold has a Claim Graph receipt linking target context, AlphaFold metrics, candidate design state, evidence findings, and exports where those records exist.

How this could be wrong

computational-only status low-confidence AlphaFold regions missing functional-site annotations no candidate yet

Candidate peptides (0)

Sequences redacted under public scope.

No candidates designed for this fold yet.

Agent findings (1)

literature C 05-01 21:04

Initial digest — OX2R

AlphaFold v6 prediction landed for **OX2R** (Orexin receptor type 2). UniProt accession: `O43614`. Lane: `sleep_circadian`. Mean per-residue pLDDT: **78.96**. ...