Oral GLP-1 with reduced albumin binding
Glucose-stimulated insulin secretion (GLP-1 / GIP wedge)
Boost glucose-stimulated insulin secretion and slow gastric emptying via incretin axis; favor dual GLP-1R / GIPR agonism, oral peptide route preferred.
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GHSR1a inverse agonist for appetite suppression
Targeted lipolysis without insulin spike (glucagon arm)
Drive hepatic and adipose lipolysis via glucagon receptor activation while sparing chronic hyperglycemia; tri-agonist or biased GCGR agonism.
Tri-agonist with biased β-arrestin signaling
Suppress appetite via central melanocortin axis
Suppress appetite via the central melanocortin pathway with selectivity over peripheral pigmentation receptors; favor MC4R agonism with low MC1R off-target activity.
Biased CXCR4 Partial Agonist for Progenitor Mobilization
A β-arrestin-biased CXCR4 ligand that mobilizes reparative progenitors without the hematologic side effects of full antagonism.
Transiently desensitizes CXCR4 via arrestin-biased signaling to release marrow-resident MSC and endothelial progenitors into circulation, enhancing homing to injured tissue. Avoids the neutrophilia an…
Target: CXCR4-TMSB4-axis
Tendon-Homing TGFB1 Latency Mimetic
A tendon-ECM-anchored peptide that locally dampens TGFB1 to steer repair away from fibrosis without systemic immunosuppression.
Selectively reduces active TGFB1 signaling at injured tendon and ligament sites, shifting healing from scar deposition toward organized collagen-I remodeling. Spares systemic TGFB1 tone, preserving im…
Target: TGFB1
FGFR1-Selective PAM for Cartilage Anabolism
A heparin-mimetic positive allosteric modulator that potentiates endogenous FGF18-FGFR1 signaling only where ligand is already present.
Amplifies chondrocyte proliferation and matrix synthesis in articular cartilage by stabilizing the FGF-FGFR1-heparan sulfate ternary complex. Activity is conditional on local FGF ligand, avoiding the …
Target: FGFR1
BPC-157 successor with extended PK
Gut barrier restoration
Restore intestinal epithelial barrier integrity and reduce permeability; favor multi-target peptide acting on GH/IGF-1 + nitric-oxide + dopaminergic pathways (BPC-157 mechanism class).
VEGFR2-tuned regenerative peptide with anti-fibrotic guard
Tendon / soft-tissue repair
Accelerate tendon and ligament repair by promoting angiogenesis and ECM remodeling; favor VEGFR2 / FGFR1 axis or thymosin-beta-4 / CXCR4 mechanism.
TB-500 / CXCR4 cyclic mimetic
Wound-healing accelerant
Speed cutaneous wound healing through capillary remodeling and fibroblast migration; favor angiogenic peptides with tight regulation to avoid pathological angiogenesis.