A tendon-ECM-anchored peptide that locally dampens TGFB1 to steer repair away from fibrosis without systemic immunosuppression.
Selectively reduces active TGFB1 signaling at injured tendon and ligament sites, shifting healing from scar deposition toward organized collagen-I remodeling. Spares systemic TGFB1 tone, preserving im…
Target: TGFB1
A β-arrestin-biased CXCR4 ligand that mobilizes reparative progenitors without the hematologic side effects of full antagonism.
Transiently desensitizes CXCR4 via arrestin-biased signaling to release marrow-resident MSC and endothelial progenitors into circulation, enhancing homing to injured tissue. Avoids the neutrophilia an…
Target: CXCR4-TMSB4-axis
A heparin-mimetic positive allosteric modulator that potentiates endogenous FGF18-FGFR1 signaling only where ligand is already present.
Amplifies chondrocyte proliferation and matrix synthesis in articular cartilage by stabilizing the FGF-FGFR1-heparan sulfate ternary complex. Activity is conditional on local FGF ligand, avoiding the …
Target: FGFR1
Gut barrier restoration
Restore intestinal epithelial barrier integrity and reduce permeability; favor multi-target peptide acting on GH/IGF-1 + nitric-oxide + dopaminergic pathways (BPC-157 mechanism class).
Wound-healing accelerant
Speed cutaneous wound healing through capillary remodeling and fibroblast migration; favor angiogenic peptides with tight regulation to avoid pathological angiogenesis.
Tendon / soft-tissue repair
Accelerate tendon and ligament repair by promoting angiogenesis and ECM remodeling; favor VEGFR2 / FGFR1 axis or thymosin-beta-4 / CXCR4 mechanism.