GHSR1a inverse agonist for appetite suppression
Targeted lipolysis without insulin spike (glucagon arm)
Drive hepatic and adipose lipolysis via glucagon receptor activation while sparing chronic hyperglycemia; tri-agonist or biased GCGR agonism.
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Targeted lipolysis without insulin spike (glucagon arm)
Drive hepatic and adipose lipolysis via glucagon receptor activation while sparing chronic hyperglycemia; tri-agonist or biased GCGR agonism.
Suppress appetite via central melanocortin axis
Suppress appetite via the central melanocortin pathway with selectivity over peripheral pigmentation receptors; favor MC4R agonism with low MC1R off-target activity.
Glucose-stimulated insulin secretion (GLP-1 / GIP wedge)
Boost glucose-stimulated insulin secretion and slow gastric emptying via incretin axis; favor dual GLP-1R / GIPR agonism, oral peptide route preferred.