IGF1R

Insulin-like growth factor 1 receptor / UniProt P08069

Fold Report v1

Model confidence, target context, and design-readiness state.

This page binds the structure viewer to AlphaFold confidence data, agent findings, redacted candidate state, and non-clinical evidence limits so every fold is inspectable before it moves into a dossier.

Structure: alphafold-cdn pLDDT: alphafold db Coverage: 100.0% PAE: AlphaFold DB Candidates: 0 Findings: 1

Mean pLDDT 78.02 Confident backbone model

Residues 1367 per-residue parsed

Coverage 100.0% 1367/1367 residues

Evidence refs 1 agent-linked items

01 / Structure

AlphaFold v6 / streamed through the structure proxy / drag to rotate / scroll to zoom

02 / Per-residue confidence

1367 residues - very high (>90) confident (70-90) low (50-70) very low (<50)

03 / AlphaFold metrics

Reference prediction from the AlphaFold Protein Structure Database: predicted aligned error (PAE) plus per-position model confidence.

Predicted aligned error

Blue regions imply stronger relative-position confidence. Red off-diagonal regions signal domain-orientation uncertainty.

Predicted lDDT per position

1367 residues / mean 78.02 / min 23.3 / max 98.0

Very high 43.6% 596 residues / >=90

Confident 31.6% 432 residues / 70-89

Low 9.1% 124 residues / 50-69

Very low 15.7% 215 residues / <50

Coverage

Near-complete coverage: 1367 observed of 1367 residues.

Low-confidence intervals

res 1286-1367 / mean 32.12 res 723-774 / mean 39.62 res 1-30 / mean 36.96 res 675-704 / mean 38.91

UniProt P08069 / open in AlphaFold DB

04 / Target context

Biological lane

recovery

Family

RTK

Pocket modes

ortho

Indication tags

anabolic, muscle_growth

Functional sites

Functional-site annotations are not cached for this target yet.

Binding partners

Binding-partner context is not cached for this target yet.

Gene ontology

GO terms are not cached for this target yet.

Residue-level functional sites, binding partners, and ontology tags are ready for ingestion but not cached for this fold yet.

Fold stats

Gene	IGF1R
Length	1367 aa
pLDDT mean	78.02
Confidence	78.02%
pLDDT source	alphafold db
Model state	Confident backbone model
Status	complete
Lane	recovery

Research-use only. Structure confidence is not biological validation; it is a model-quality receipt for downstream evidence grading.

Markdown export Proof spine Learning loop

Proof spine

This fold has a Claim Graph receipt linking target context, AlphaFold metrics, candidate design state, evidence findings, and exports where those records exist.

How this could be wrong

computational-only status low-confidence AlphaFold regions missing functional-site annotations no candidate yet

Candidate peptides (0)

Sequences redacted under public scope.

No candidates designed for this fold yet.

Agent findings (1)

literature C 05-01 21:04

Initial digest — IGF1R

AlphaFold v6 prediction landed for **IGF1R** (Insulin-like growth factor 1 receptor). UniProt accession: `P08069`. Lane: `recovery`. Mean per-residue pLDDT: **7...