Peptide RX

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proof receipt / finding

Initial digest — MCHR1

AlphaFold v6 prediction landed for **MCHR1** (Melanin-concentrating hormone receptor 1). UniProt accession: `Q99705`. Lane: `sleep_circadian`. Mean per-residue pLDDT: **84.43**. _(no notes)_

grade C status literature receipt 22c3ff86033a proof 33%

what this node claims

Initial digest — MCHR1

AlphaFold v6 prediction landed for **MCHR1** (Melanin-concentrating hormone receptor 1). UniProt accession: `Q99705`. Lane: `sleep_circadian`. Mean per-residue pLDDT: **84.43**. _(no notes)_

evidence / risk instrument

39%
thin proof
structure evidence gates risk export lineage 39
low debt pressure 29%
28%structuredebt
pLDDT pending
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
33%lineagedebt
incomplete spine

proof completeness

33% missing target, alphafold_metric, candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence
0.6
evidence refs
1

AlphaFold metrics visual

Confident backbone model

84.4

353 residues / min 21.73 / max 98.56 / source alphafold db

PAE matrix for linked target
Very high 63.5% 224 residues / >=90
Confident 20.4% 72 residues / 70-89
Low 6.8% 24 residues / 50-69
Very low 9.3% 33 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 353 of 353 residues.

  • residues 1-39 / mean 35.94
  • residues 327-336 / mean 57.7
  • residues 69-74 / mean 55.9
  • residues 352-353 / mean 59.09
proof debt register

Visible limits, not hidden cleanup.

29%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

high low evidence grade attach graded finding with source-linked evidence
low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
low evidence grade high blocks weakens attach graded finding with source-linked evidence
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it

what supports it

evidence finding attached fold:35d6975c-1020-4857-9bb1-ff5183e910c1 -> finding:331347b2-f315-4f04-8ebf-6a8d70562021 supports / C / 0.6

what it supports

No downstream proof edge yet.

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.