Peptide RX

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proof receipt / fold

NTRK1 WT

Structure prediction with public confidence context.

grade B status complete receipt 499f7c574c89 proof 67%

what this node claims

NTRK1 WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 NTRK1 WT fold / grade B / 62% 2 debt
  2. 02 AlphaFold metrics / NTRK1 alphafold metric / grade B / 70% 1 debt
  3. 03 Initial digest — TrkA finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 TrkA target / grade B / 70% 1 debt

evidence / risk instrument

50%
thin proof
structure evidence gates risk export lineage 50
visible debt pressure 47%
78%structureusable
pLDDT 78.23
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
confident
confidence pct
78.23
coverage available
false
gene
NTRK1
has structure
true
pae available
false
plddt avg
78.23
sequence length
0
variant
WT

AlphaFold metrics visual

Confident backbone model

78.2

796 residues / min 23.58 / max 98.62 / source alphafold db

PAE matrix for linked target
Very high 37.6% 299 residues / >=90
Confident 38.1% 303 residues / 70-89
Low 9.4% 75 residues / 50-69
Very low 14.9% 119 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 796 of 796 residues.

  • residues 441-500 / mean 35.47
  • residues 1-38 / mean 37.89
  • residues 381-418 / mean 44.3
  • residues 668-675 / mean 54.61
proof debt register

Visible limits, not hidden cleanup.

47%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:b8ff9ca2-f9a6-47a8-a2f6-ca38ae5bff5e -> fold:25e30310-af17-440f-99af-a61d469b4adf folds_to / B / 0.782

what it supports

measured by AlphaFold confidence context fold:25e30310-af17-440f-99af-a61d469b4adf -> alphafold_metric:25e30310-af17-440f-99af-a61d469b4adf measured_by / B / 0.782
evidence finding attached fold:25e30310-af17-440f-99af-a61d469b4adf -> finding:3767f7b9-68bc-4cf7-ba5f-969415cdf55c supports / C / 0.6
timeline records state change fold:25e30310-af17-440f-99af-a61d469b4adf -> timeline_event:22 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.