Peptide RX

back to claim graph

proof receipt / fold

MC3R WT

Structure prediction with public confidence context.

grade B status complete receipt c9a5f2fb6637 proof 67%

what this node claims

MC3R WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 MC3R WT fold / grade B / 68% 2 debt
  2. 02 AlphaFold metrics / MC3R alphafold metric / grade B / 76% 1 debt
  3. 03 Initial digest — MC3R finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 MC3R target / grade B / 70% 1 debt

evidence / risk instrument

51%
thin proof
structure evidence gates risk export lineage 51
visible debt pressure 47%
84%structurestrong
pLDDT 83.87
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
confident
confidence pct
83.87
coverage available
false
gene
MC3R
has structure
true
pae available
false
plddt avg
83.87
sequence length
0
variant
WT

AlphaFold metrics visual

Confident backbone model

83.9

323 residues / min 25.95 / max 98.56 / source alphafold db

PAE matrix for linked target
Very high 61.9% 200 residues / >=90
Confident 21.1% 68 residues / 70-89
Low 5.9% 19 residues / 50-69
Very low 11.1% 36 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 323 of 323 residues.

  • residues 1-34 / mean 36.2
  • residues 227-240 / mean 61.99
  • residues 317-323 / mean 49.82
proof debt register

Visible limits, not hidden cleanup.

47%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:50f7b6d1-d9e4-4a24-a39a-ca9f0f52c375 -> fold:3d857094-fbe0-4e67-9664-a427b838225e folds_to / B / 0.839

what it supports

measured by AlphaFold confidence context fold:3d857094-fbe0-4e67-9664-a427b838225e -> alphafold_metric:3d857094-fbe0-4e67-9664-a427b838225e measured_by / B / 0.839
evidence finding attached fold:3d857094-fbe0-4e67-9664-a427b838225e -> finding:791f8d97-01ea-4176-b047-d7160213b722 supports / C / 0.6
timeline records state change fold:3d857094-fbe0-4e67-9664-a427b838225e -> timeline_event:14 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.