Peptide RX

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proof receipt / fold

MTNR1A WT

Structure prediction with public confidence context.

grade B status complete receipt 4eddf473f21b proof 67%

what this node claims

MTNR1A WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 MTNR1A WT fold / grade B / 70% 2 debt
  2. 02 AlphaFold metrics / MTNR1A alphafold metric / grade B / 78% 1 debt
  3. 03 Initial digest — MTNR1A finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 MTNR1A target / grade B / 70% 1 debt

evidence / risk instrument

51%
thin proof
structure evidence gates risk export lineage 51
visible debt pressure 47%
86%structurestrong
pLDDT 85.73
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
confident
confidence pct
85.73
coverage available
false
gene
MTNR1A
has structure
true
pae available
false
plddt avg
85.73
sequence length
0
variant
WT

AlphaFold metrics visual

Confident backbone model

85.7

350 residues / min 31.48 / max 98.56 / source alphafold db

PAE matrix for linked target
Very high 68.3% 239 residues / >=90
Confident 14.9% 52 residues / 70-89
Low 6.3% 22 residues / 50-69
Very low 10.6% 37 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 350 of 350 residues.

  • residues 318-350 / mean 51.52
  • residues 1-21 / mean 39.9
  • residues 225-228 / mean 64.66
  • residues 223-223 / mean 66.19
proof debt register

Visible limits, not hidden cleanup.

47%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:94a610ac-d1e3-4815-9569-e401a92abc35 -> fold:3f539ad6-4d5b-4fa2-bb4a-990ba26dcfee folds_to / B / 0.857

what it supports

measured by AlphaFold confidence context fold:3f539ad6-4d5b-4fa2-bb4a-990ba26dcfee -> alphafold_metric:3f539ad6-4d5b-4fa2-bb4a-990ba26dcfee measured_by / B / 0.857
evidence finding attached fold:3f539ad6-4d5b-4fa2-bb4a-990ba26dcfee -> finding:8225da1f-fc02-4171-8bfb-6380f801403d supports / C / 0.6
timeline records state change fold:3f539ad6-4d5b-4fa2-bb4a-990ba26dcfee -> timeline_event:39 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.