Peptide RX

back to claim graph

proof receipt / fold

GHRHR WT

Structure prediction with public confidence context.

grade B status complete receipt b8ff0d7c6ede proof 67%

what this node claims

GHRHR WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 GHRHR WT fold / grade B / 62% 2 debt
  2. 02 AlphaFold metrics / GHRHR alphafold metric / grade B / 70% 1 debt
  3. 03 Initial digest — GHRHR finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 GHRHR target / grade B / 70% 1 debt

evidence / risk instrument

49%
thin proof
structure evidence gates risk export lineage 49
visible debt pressure 47%
76%structureusable
pLDDT 75.82
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
confident
confidence pct
75.82
coverage available
false
gene
GHRHR
has structure
true
pae available
false
plddt avg
75.82
sequence length
0
variant
WT

AlphaFold metrics visual

Confident backbone model

75.8

423 residues / min 30.53 / max 97.0 / source alphafold db

PAE matrix for linked target
Very high 26.5% 112 residues / >=90
Confident 41.4% 175 residues / 70-89
Low 20.1% 85 residues / 50-69
Very low 12.1% 51 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 423 of 423 residues.

  • residues 393-423 / mean 40.48
  • residues 1-29 / mean 39.9
  • residues 313-328 / mean 60.18
  • residues 343-358 / mean 63.55
proof debt register

Visible limits, not hidden cleanup.

47%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:df0f6a4f-7086-4900-8ba9-2840be18871b -> fold:aa890750-0042-4492-8021-447fa129fe4f folds_to / B / 0.758

what it supports

measured by AlphaFold confidence context fold:aa890750-0042-4492-8021-447fa129fe4f -> alphafold_metric:aa890750-0042-4492-8021-447fa129fe4f measured_by / B / 0.758
evidence finding attached fold:aa890750-0042-4492-8021-447fa129fe4f -> finding:e034bdd3-db43-42cb-be97-7c8a2de54bd9 supports / C / 0.6
timeline records state change fold:aa890750-0042-4492-8021-447fa129fe4f -> timeline_event:13 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.