Peptide RX

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proof receipt / target

OX2R

Orexin receptor type 2

grade B status sleep_circadian receipt 6683bb2937ae proof 33%

what this node claims

OX2R

Orexin receptor type 2

Open source surface

vertical proof spine

  1. 01 OX2R target / grade B / 70% 1 debt
  2. 02 HCRTR2 WT fold / grade B / 63% 2 debt

evidence / risk instrument

44%
thin proof
structure evidence gates risk export lineage 44
low debt pressure 21%
28%structuredebt
pLDDT pending
78%evidenceusable
grade B
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
33%lineagedebt
incomplete spine

proof completeness

33% missing alphafold_metric, candidate, finding, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

binding partners
    context annotations
    0
    family
    GPCR_class_A
    functional sites
      gene symbol
      HCRTR2
      go terms
        uniprot
        O43614

        AlphaFold metrics visual

        Confident backbone model

        79.0

        444 residues / min 32.28 / max 98.69 / source alphafold db

        PAE matrix for linked target
        Very high 52.0% 231 residues / >=90
        Confident 16.7% 74 residues / 70-89
        Low 14.9% 66 residues / 50-69
        Very low 16.4% 73 residues / <50

        usable fold context with explicit model-confidence limits

        Near-complete coverage / observed 444 of 444 residues.

        • residues 384-444 / mean 49.88
        • residues 1-34 / mean 41.73
        • residues 253-286 / mean 50.91
        • residues 197-206 / mean 57.07
        proof debt register

        Visible limits, not hidden cleanup.

        21%

        Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

        medium missing functional-site annotations link target annotation, GO term, or binding-site context
        low computational-only status add independent evidence, challenge result, or witness review before strengthening
        medium no candidate yet leave visible until a stronger public receipt resolves it

        weakness and challenge edges

        What would stop this from becoming stronger.

        debt severity export claim strength next proof needed
        missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context
        computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
        no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it

        what supports it

        No upstream proof edge yet.

        what it supports

        target has structure prediction target:cf7d82a7-1b56-4cd6-9428-ba4eec232f28 -> fold:05b968cf-a48c-4000-8e51-b740fcffcba5 folds_to / B / 0.79

        Research-use boundary

        This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.