Peptide RX

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proof receipt / target

TLR4

Toll-like receptor 4

grade B status immune_resilience receipt bc72ba5f60e2 proof 33%

what this node claims

TLR4

Toll-like receptor 4

Open source surface

vertical proof spine

  1. 01 TLR4 target / grade B / 70% 1 debt
  2. 02 TLR4 WT fold / grade B / 73% 2 debt

evidence / risk instrument

44%
thin proof
structure evidence gates risk export lineage 44
low debt pressure 21%
28%structuredebt
pLDDT pending
78%evidenceusable
grade B
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
33%lineagedebt
incomplete spine

proof completeness

33% missing alphafold_metric, candidate, finding, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

binding partners
    context annotations
    0
    family
    pattern_recognition_R
    functional sites
      gene symbol
      TLR4
      go terms
        uniprot
        O00206

        AlphaFold metrics visual

        Confident backbone model

        89.2

        839 residues / min 28.11 / max 98.94 / source alphafold db

        PAE matrix for linked target
        Very high 71.6% 601 residues / >=90
        Confident 18.5% 155 residues / 70-89
        Low 4.4% 37 residues / 50-69
        Very low 5.5% 46 residues / <50

        usable fold context with explicit model-confidence limits

        Near-complete coverage / observed 839 of 839 residues.

        • residues 1-27 / mean 41.1
        • residues 818-839 / mean 39.07
        • residues 656-672 / mean 58.09
        • residues 627-632 / mean 62.26
        proof debt register

        Visible limits, not hidden cleanup.

        21%

        Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

        medium missing functional-site annotations link target annotation, GO term, or binding-site context
        low computational-only status add independent evidence, challenge result, or witness review before strengthening
        medium no candidate yet leave visible until a stronger public receipt resolves it

        weakness and challenge edges

        What would stop this from becoming stronger.

        debt severity export claim strength next proof needed
        missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context
        computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
        no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it

        what supports it

        No upstream proof edge yet.

        what it supports

        target has structure prediction target:d40ebc37-a224-484b-a874-4fd5f8b1e782 -> fold:734dc955-128d-4d32-a2fb-2a0432b49d56 folds_to / B / 0.892

        Research-use boundary

        This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.