KDR

Vascular endothelial growth factor receptor 2 / UniProt P35968

Fold Report v1

Model confidence, target context, and design-readiness state.

This page binds the structure viewer to AlphaFold confidence data, agent findings, redacted candidate state, and non-clinical evidence limits so every fold is inspectable before it moves into a dossier.

Structure: alphafold-cdn pLDDT: alphafold db Coverage: 100.0% PAE: AlphaFold DB Candidates: 0 Findings: 1

Mean pLDDT 71.14 Confident backbone model

Residues 1356 per-residue parsed

Coverage 100.0% 1356/1356 residues

Evidence refs 1 agent-linked items

01 / Structure

AlphaFold v6 / streamed through the structure proxy / drag to rotate / scroll to zoom

02 / Per-residue confidence

1356 residues - very high (>90) confident (70-90) low (50-70) very low (<50)

03 / AlphaFold metrics

Reference prediction from the AlphaFold Protein Structure Database: predicted aligned error (PAE) plus per-position model confidence.

Predicted aligned error

Blue regions imply stronger relative-position confidence. Red off-diagonal regions signal domain-orientation uncertainty.

Predicted lDDT per position

1356 residues / mean 71.14 / min 24.44 / max 97.69

Very high 23.5% 318 residues / >=90

Confident 43.4% 589 residues / 70-89

Low 7.6% 103 residues / 50-69

Very low 25.5% 346 residues / <50

Coverage

Near-complete coverage: 1356 observed of 1356 residues.

Low-confidence intervals

res 1240-1356 / mean 32.49 res 1167-1236 / mean 32.26 res 937-999 / mean 31.96 res 785-822 / mean 39.87

UniProt P35968 / open in AlphaFold DB

04 / Target context

Biological lane

recovery

Family

RTK

Pocket modes

ortho, ppi

Indication tags

angiogenesis, wound_healing

Functional sites

Functional-site annotations are not cached for this target yet.

Binding partners

Binding-partner context is not cached for this target yet.

Gene ontology

GO terms are not cached for this target yet.

Residue-level functional sites, binding partners, and ontology tags are ready for ingestion but not cached for this fold yet.

Fold stats

Gene	KDR
Length	1356 aa
pLDDT mean	71.14
Confidence	71.14%
pLDDT source	alphafold db
Model state	Confident backbone model
Status	complete
Lane	recovery

Research-use only. Structure confidence is not biological validation; it is a model-quality receipt for downstream evidence grading.

Markdown export Proof spine Learning loop

Proof spine

This fold has a Claim Graph receipt linking target context, AlphaFold metrics, candidate design state, evidence findings, and exports where those records exist.

How this could be wrong

computational-only status low-confidence AlphaFold regions missing functional-site annotations no candidate yet

Candidate peptides (0)

Sequences redacted under public scope.

No candidates designed for this fold yet.

Agent findings (1)

literature C 05-01 21:04

Initial digest — VEGFR2

AlphaFold v6 prediction landed for **VEGFR2** (Vascular endothelial growth factor receptor 2). UniProt accession: `P35968`. Lane: `recovery`. Mean per-residue p...