Peptide RX

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proof receipt / fold

KDR WT

Structure prediction with public confidence context.

grade B status complete receipt 9a948806ff6f proof 67%

what this node claims

KDR WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 KDR WT fold / grade B / 62% 2 debt
  2. 02 AlphaFold metrics / KDR alphafold metric / grade B / 70% 1 debt
  3. 03 Initial digest — VEGFR2 finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 VEGFR2 target / grade B / 70% 1 debt

evidence / risk instrument

49%
thin proof
structure evidence gates risk export lineage 49
visible debt pressure 47%
71%structureusable
pLDDT 71.14
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
confident
confidence pct
71.14
coverage available
false
gene
KDR
has structure
true
pae available
false
plddt avg
71.14
sequence length
0
variant
WT

AlphaFold metrics visual

Confident backbone model

71.1

1356 residues / min 24.44 / max 97.69 / source alphafold db

PAE matrix for linked target
Very high 23.5% 318 residues / >=90
Confident 43.4% 589 residues / 70-89
Low 7.6% 103 residues / 50-69
Very low 25.5% 346 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 1356 of 1356 residues.

  • residues 1240-1356 / mean 32.49
  • residues 1167-1236 / mean 32.26
  • residues 937-999 / mean 31.96
  • residues 785-822 / mean 39.87
proof debt register

Visible limits, not hidden cleanup.

47%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:ce831bd5-507f-49e0-837b-bd8fa4acdd10 -> fold:000266a5-9129-4f8f-b9d5-e0216c573655 folds_to / B / 0.711

what it supports

measured by AlphaFold confidence context fold:000266a5-9129-4f8f-b9d5-e0216c573655 -> alphafold_metric:000266a5-9129-4f8f-b9d5-e0216c573655 measured_by / B / 0.711
evidence finding attached fold:000266a5-9129-4f8f-b9d5-e0216c573655 -> finding:a784a3ae-6879-4fe5-8bf5-c1cd7555be14 supports / C / 0.6
timeline records state change fold:000266a5-9129-4f8f-b9d5-e0216c573655 -> timeline_event:18 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.