Peptide RX

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NTRK2

Tropomyosin receptor kinase B (BDNF receptor) / UniProt Q16620

Fold Report v1

Model confidence, target context, and design-readiness state.

This page binds the structure viewer to AlphaFold confidence data, agent findings, redacted candidate state, and non-clinical evidence limits so every fold is inspectable before it moves into a dossier.

Structure: alphafold-cdn pLDDT: alphafold db Coverage: 100.0% PAE: AlphaFold DB Candidates: 0 Findings: 1
Mean pLDDT 76.97 Confident backbone model
Residues 822 per-residue parsed
Coverage 100.0% 822/822 residues
Evidence refs 1 agent-linked items

01 / Structure

AlphaFold v6 / streamed through the structure proxy / drag to rotate / scroll to zoom

02 / Per-residue confidence

822 residues - very high (>90) confident (70-90) low (50-70) very low (<50)

03 / AlphaFold metrics

Reference prediction from the AlphaFold Protein Structure Database: predicted aligned error (PAE) plus per-position model confidence.

Predicted aligned error

PAE matrix for TrkB

Blue regions imply stronger relative-position confidence. Red off-diagonal regions signal domain-orientation uncertainty.

Predicted lDDT per position

822 residues / mean 76.97 / min 23.52 / max 98.38

Very high 44.3% 364 residues / >=90
Confident 29.6% 243 residues / 70-89
Low 7.3% 60 residues / 50-69
Very low 18.9% 155 residues / <50

Coverage

Near-complete coverage: 822 observed of 822 residues.

Low-confidence intervals

res 455-528 / mean 32.1 res 382-435 / mean 38.95 res 1-31 / mean 36.34 res 694-703 / mean 57.27

UniProt Q16620 / open in AlphaFold DB

04 / Target context

Biological lane

cognitive

Family

RTK

Pocket modes

ortho, allo

Indication tags

neuroplasticity, depression, stroke_recovery

Functional sites

Functional-site annotations are not cached for this target yet.

Binding partners

Binding-partner context is not cached for this target yet.

Gene ontology

GO terms are not cached for this target yet.

Residue-level functional sites, binding partners, and ontology tags are ready for ingestion but not cached for this fold yet.