SIRT1

NAD-dependent deacetylase sirtuin-1 / UniProt Q96EB6

Fold Report v1

Model confidence, target context, and design-readiness state.

This page binds the structure viewer to AlphaFold confidence data, agent findings, redacted candidate state, and non-clinical evidence limits so every fold is inspectable before it moves into a dossier.

Structure: alphafold-cdn pLDDT: alphafold db Coverage: 100.0% PAE: AlphaFold DB Candidates: 0 Findings: 1

Mean pLDDT 65.02 Low-confidence regions present

Residues 747 per-residue parsed

Coverage 100.0% 747/747 residues

Evidence refs 1 agent-linked items

01 / Structure

AlphaFold v6 / streamed through the structure proxy / drag to rotate / scroll to zoom

02 / Per-residue confidence

747 residues - very high (>90) confident (70-90) low (50-70) very low (<50)

03 / AlphaFold metrics

Reference prediction from the AlphaFold Protein Structure Database: predicted aligned error (PAE) plus per-position model confidence.

Predicted aligned error

Blue regions imply stronger relative-position confidence. Red off-diagonal regions signal domain-orientation uncertainty.

Predicted lDDT per position

747 residues / mean 65.02 / min 24.66 / max 98.88

Very high 36.9% 276 residues / >=90

Confident 13.0% 97 residues / 70-89

Low 3.5% 26 residues / 50-69

Very low 46.6% 348 residues / <50

Coverage

Near-complete coverage: 747 observed of 747 residues.

Low-confidence intervals

res 1-148 / mean 37.74 res 517-630 / mean 36.16 res 660-747 / mean 37.45 res 155-177 / mean 48.56

UniProt Q96EB6 / open in AlphaFold DB

04 / Target context

Biological lane

longevity

Family

sirtuin

Pocket modes

allo

Indication tags

caloric_restriction, metabolic_health

Functional sites

Functional-site annotations are not cached for this target yet.

Binding partners

Binding-partner context is not cached for this target yet.

Gene ontology

GO terms are not cached for this target yet.

Residue-level functional sites, binding partners, and ontology tags are ready for ingestion but not cached for this fold yet.

Fold stats

Gene	SIRT1
Length	747 aa
pLDDT mean	65.02
Confidence	65.02%
pLDDT source	alphafold db
Model state	Low-confidence regions present
Status	complete
Lane	longevity

Research-use only. Structure confidence is not biological validation; it is a model-quality receipt for downstream evidence grading.

Markdown export Proof spine Learning loop

Proof spine

This fold has a Claim Graph receipt linking target context, AlphaFold metrics, candidate design state, evidence findings, and exports where those records exist.

How this could be wrong

computational-only status low-confidence AlphaFold regions missing functional-site annotations no candidate yet

Candidate peptides (0)

Sequences redacted under public scope.

No candidates designed for this fold yet.

Agent findings (1)

literature C 05-01 21:04

Initial digest — SIRT1

AlphaFold v6 prediction landed for **SIRT1** (NAD-dependent deacetylase sirtuin-1). UniProt accession: `Q96EB6`. Lane: `longevity`. Mean per-residue pLDDT: **65...