HTR1A

Serotonin receptor 5-HT1A / UniProt P08908

Fold Report v1

Model confidence, target context, and design-readiness state.

This page binds the structure viewer to AlphaFold confidence data, agent findings, redacted candidate state, and non-clinical evidence limits so every fold is inspectable before it moves into a dossier.

Structure: alphafold-cdn pLDDT: alphafold db Coverage: 100.0% PAE: AlphaFold DB Candidates: 0 Findings: 1

Mean pLDDT 77.81 Confident backbone model

Residues 422 per-residue parsed

Coverage 100.0% 422/422 residues

Evidence refs 1 agent-linked items

01 / Structure

AlphaFold v6 / streamed through the structure proxy / drag to rotate / scroll to zoom

02 / Per-residue confidence

422 residues - very high (>90) confident (70-90) low (50-70) very low (<50)

03 / AlphaFold metrics

Reference prediction from the AlphaFold Protein Structure Database: predicted aligned error (PAE) plus per-position model confidence.

Predicted aligned error

Blue regions imply stronger relative-position confidence. Red off-diagonal regions signal domain-orientation uncertainty.

Predicted lDDT per position

422 residues / mean 77.81 / min 26.25 / max 98.31

Very high 51.7% 218 residues / >=90

Confident 20.6% 87 residues / 70-89

Low 5.0% 21 residues / 50-69

Very low 22.7% 96 residues / <50

Coverage

Near-complete coverage: 422 observed of 422 residues.

Low-confidence intervals

res 236-322 / mean 38.61 res 1-25 / mean 46.21 res 418-422 / mean 54.76

UniProt P08908 / open in AlphaFold DB

04 / Target context

Biological lane

cognitive

Family

GPCR_class_A

Pocket modes

ortho

Indication tags

anxiety, mood

Functional sites

Functional-site annotations are not cached for this target yet.

Binding partners

Binding-partner context is not cached for this target yet.

Gene ontology

GO terms are not cached for this target yet.

Residue-level functional sites, binding partners, and ontology tags are ready for ingestion but not cached for this fold yet.

Fold stats

Gene	HTR1A
Length	422 aa
pLDDT mean	77.81
Confidence	77.81%
pLDDT source	alphafold db
Model state	Confident backbone model
Status	complete
Lane	cognitive

Research-use only. Structure confidence is not biological validation; it is a model-quality receipt for downstream evidence grading.

Markdown export Proof spine Learning loop

Proof spine

This fold has a Claim Graph receipt linking target context, AlphaFold metrics, candidate design state, evidence findings, and exports where those records exist.

How this could be wrong

computational-only status low-confidence AlphaFold regions missing functional-site annotations no candidate yet

Candidate peptides (0)

Sequences redacted under public scope.

No candidates designed for this fold yet.

Agent findings (1)

literature C 05-01 21:04

Initial digest — HTR1A

AlphaFold v6 prediction landed for **HTR1A** (Serotonin receptor 5-HT1A). UniProt accession: `P08908`. Lane: `cognitive`. Mean per-residue pLDDT: **77.81**. _(...