Peptide RX

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proof receipt / fold

HTR1A WT

Structure prediction with public confidence context.

grade B status complete receipt 0b4da4cc07f3 proof 67%

what this node claims

HTR1A WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 HTR1A WT fold / grade B / 62% 2 debt
  2. 02 AlphaFold metrics / HTR1A alphafold metric / grade B / 70% 1 debt
  3. 03 Initial digest — HTR1A finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 HTR1A target / grade B / 70% 1 debt

evidence / risk instrument

50%
thin proof
structure evidence gates risk export lineage 50
visible debt pressure 47%
78%structureusable
pLDDT 77.81
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
confident
confidence pct
77.81
coverage available
false
gene
HTR1A
has structure
true
pae available
false
plddt avg
77.81
sequence length
0
variant
WT

AlphaFold metrics visual

Confident backbone model

77.8

422 residues / min 26.25 / max 98.31 / source alphafold db

PAE matrix for linked target
Very high 51.7% 218 residues / >=90
Confident 20.6% 87 residues / 70-89
Low 5.0% 21 residues / 50-69
Very low 22.7% 96 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 422 of 422 residues.

  • residues 236-322 / mean 38.61
  • residues 1-25 / mean 46.21
  • residues 418-422 / mean 54.76
proof debt register

Visible limits, not hidden cleanup.

47%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:f95a2676-71dc-4436-b7a7-349dff64e118 -> fold:3e086785-6c66-4693-84f6-efcc2ade976f folds_to / B / 0.778

what it supports

measured by AlphaFold confidence context fold:3e086785-6c66-4693-84f6-efcc2ade976f -> alphafold_metric:3e086785-6c66-4693-84f6-efcc2ade976f measured_by / B / 0.778
evidence finding attached fold:3e086785-6c66-4693-84f6-efcc2ade976f -> finding:eec525de-3335-4c8f-b14b-70e00c9c169c supports / C / 0.6
timeline records state change fold:3e086785-6c66-4693-84f6-efcc2ade976f -> timeline_event:25 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.