NTRK3

Tropomyosin receptor kinase C (NT-3 receptor) / UniProt Q16288

Fold Report v1

Model confidence, target context, and design-readiness state.

This page binds the structure viewer to AlphaFold confidence data, agent findings, redacted candidate state, and non-clinical evidence limits so every fold is inspectable before it moves into a dossier.

Structure: alphafold-cdn pLDDT: alphafold db Coverage: 100.0% PAE: AlphaFold DB Candidates: 0 Findings: 1

Mean pLDDT 76.82 Confident backbone model

Residues 839 per-residue parsed

Coverage 100.0% 839/839 residues

Evidence refs 1 agent-linked items

01 / Structure

AlphaFold v6 / streamed through the structure proxy / drag to rotate / scroll to zoom

02 / Per-residue confidence

839 residues - very high (>90) confident (70-90) low (50-70) very low (<50)

03 / AlphaFold metrics

Reference prediction from the AlphaFold Protein Structure Database: predicted aligned error (PAE) plus per-position model confidence.

Predicted aligned error

Blue regions imply stronger relative-position confidence. Red off-diagonal regions signal domain-orientation uncertainty.

Predicted lDDT per position

839 residues / mean 76.82 / min 25.5 / max 98.44

Very high 46.6% 391 residues / >=90

Confident 25.1% 211 residues / 70-89

Low 8.0% 67 residues / 50-69

Very low 20.3% 170 residues / <50

Coverage

Near-complete coverage: 839 observed of 839 residues.

Low-confidence intervals

res 456-528 / mean 31.76 res 399-433 / mean 44.54 res 697-731 / mean 49.84 res 1-31 / mean 33.75

UniProt Q16288 / open in AlphaFold DB

04 / Target context

Biological lane

cognitive

Family

RTK

Pocket modes

ortho

Indication tags

proprioception, neuroplasticity

Functional sites

Functional-site annotations are not cached for this target yet.

Binding partners

Binding-partner context is not cached for this target yet.

Gene ontology

GO terms are not cached for this target yet.

Residue-level functional sites, binding partners, and ontology tags are ready for ingestion but not cached for this fold yet.

Fold stats

Gene	NTRK3
Length	839 aa
pLDDT mean	76.82
Confidence	76.82%
pLDDT source	alphafold db
Model state	Confident backbone model
Status	complete
Lane	cognitive

Research-use only. Structure confidence is not biological validation; it is a model-quality receipt for downstream evidence grading.

Markdown export Proof spine Learning loop

Proof spine

This fold has a Claim Graph receipt linking target context, AlphaFold metrics, candidate design state, evidence findings, and exports where those records exist.

How this could be wrong

computational-only status low-confidence AlphaFold regions missing functional-site annotations no candidate yet

Candidate peptides (0)

Sequences redacted under public scope.

No candidates designed for this fold yet.

Agent findings (1)

literature C 05-01 21:04

Initial digest — TrkC

AlphaFold v6 prediction landed for **TrkC** (Tropomyosin receptor kinase C (NT-3 receptor)). UniProt accession: `Q16288`. Lane: `cognitive`. Mean per-residue pL...