Peptide RX

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proof receipt / fold

NTRK3 WT

Structure prediction with public confidence context.

grade B status complete receipt a2025da6aa05 proof 67%

what this node claims

NTRK3 WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 NTRK3 WT fold / grade B / 62% 2 debt
  2. 02 AlphaFold metrics / NTRK3 alphafold metric / grade B / 70% 1 debt
  3. 03 Initial digest — TrkC finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 TrkC target / grade B / 70% 1 debt

evidence / risk instrument

50%
thin proof
structure evidence gates risk export lineage 50
visible debt pressure 47%
77%structureusable
pLDDT 76.82
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
confident
confidence pct
76.82
coverage available
false
gene
NTRK3
has structure
true
pae available
false
plddt avg
76.82
sequence length
0
variant
WT

AlphaFold metrics visual

Confident backbone model

76.8

839 residues / min 25.5 / max 98.44 / source alphafold db

PAE matrix for linked target
Very high 46.6% 391 residues / >=90
Confident 25.1% 211 residues / 70-89
Low 8.0% 67 residues / 50-69
Very low 20.3% 170 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 839 of 839 residues.

  • residues 456-528 / mean 31.76
  • residues 399-433 / mean 44.54
  • residues 697-731 / mean 49.84
  • residues 1-31 / mean 33.75
proof debt register

Visible limits, not hidden cleanup.

47%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:3e7e0df5-1034-4f22-beea-cecc8a9a4125 -> fold:4b7f8d01-d72c-4fe8-89b7-4c0e458b3fc7 folds_to / B / 0.768

what it supports

measured by AlphaFold confidence context fold:4b7f8d01-d72c-4fe8-89b7-4c0e458b3fc7 -> alphafold_metric:4b7f8d01-d72c-4fe8-89b7-4c0e458b3fc7 measured_by / B / 0.768
evidence finding attached fold:4b7f8d01-d72c-4fe8-89b7-4c0e458b3fc7 -> finding:c6398cc6-5469-49ca-ac30-1c3cf7d1e892 supports / C / 0.6
timeline records state change fold:4b7f8d01-d72c-4fe8-89b7-4c0e458b3fc7 -> timeline_event:23 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.