TGFB1

Transforming growth factor beta-1 / UniProt P01137

Fold Report v1

Model confidence, target context, and design-readiness state.

This page binds the structure viewer to AlphaFold confidence data, agent findings, redacted candidate state, and non-clinical evidence limits so every fold is inspectable before it moves into a dossier.

Structure: alphafold-cdn pLDDT: alphafold db Coverage: 100.0% PAE: AlphaFold DB Candidates: 0 Findings: 1

Mean pLDDT 79.59 Confident backbone model

Residues 390 per-residue parsed

Coverage 100.0% 390/390 residues

Evidence refs 1 agent-linked items

01 / Structure

AlphaFold v6 / streamed through the structure proxy / drag to rotate / scroll to zoom

02 / Per-residue confidence

390 residues - very high (>90) confident (70-90) low (50-70) very low (<50)

03 / AlphaFold metrics

Reference prediction from the AlphaFold Protein Structure Database: predicted aligned error (PAE) plus per-position model confidence.

Predicted aligned error

Blue regions imply stronger relative-position confidence. Red off-diagonal regions signal domain-orientation uncertainty.

Predicted lDDT per position

390 residues / mean 79.59 / min 36.41 / max 97.88

Very high 40.3% 157 residues / >=90

Confident 32.3% 126 residues / 70-89

Low 20.8% 81 residues / 50-69

Very low 6.7% 26 residues / <50

Coverage

Near-complete coverage: 390 observed of 390 residues.

Low-confidence intervals

res 1-36 / mean 47.64 res 269-291 / mean 54.88 res 92-104 / mean 57.73 res 240-252 / mean 60.56

UniProt P01137 / open in AlphaFold DB

04 / Target context

Biological lane

recovery

Family

cytokine

Pocket modes

ppi

Indication tags

fibrosis, regeneration

Functional sites

Functional-site annotations are not cached for this target yet.

Binding partners

Binding-partner context is not cached for this target yet.

Gene ontology

GO terms are not cached for this target yet.

Residue-level functional sites, binding partners, and ontology tags are ready for ingestion but not cached for this fold yet.

Fold stats

Gene	TGFB1
Length	390 aa
pLDDT mean	79.59
Confidence	79.59%
pLDDT source	alphafold db
Model state	Confident backbone model
Status	complete
Lane	recovery

Research-use only. Structure confidence is not biological validation; it is a model-quality receipt for downstream evidence grading.

Markdown export Proof spine Learning loop

Proof spine

This fold has a Claim Graph receipt linking target context, AlphaFold metrics, candidate design state, evidence findings, and exports where those records exist.

How this could be wrong

computational-only status low-confidence AlphaFold regions missing functional-site annotations no candidate yet

Candidate peptides (0)

Sequences redacted under public scope.

No candidates designed for this fold yet.

Agent findings (1)

literature C 05-01 21:04

Initial digest — TGFB1

AlphaFold v6 prediction landed for **TGFB1** (Transforming growth factor beta-1). UniProt accession: `P01137`. Lane: `recovery`. Mean per-residue pLDDT: **79.59...