Peptide RX

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proof receipt / fold

TGFB1 WT

Structure prediction with public confidence context.

grade B status complete receipt c13b77bca3f4 proof 67%

what this node claims

TGFB1 WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 TGFB1 WT fold / grade B / 64% 2 debt
  2. 02 AlphaFold metrics / TGFB1 alphafold metric / grade B / 72% 1 debt
  3. 03 Initial digest — TGFB1 finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 TGFB1 target / grade B / 70% 1 debt

evidence / risk instrument

50%
thin proof
structure evidence gates risk export lineage 50
visible debt pressure 47%
80%structureusable
pLDDT 79.59
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
confident
confidence pct
79.59
coverage available
false
gene
TGFB1
has structure
true
pae available
false
plddt avg
79.59
sequence length
0
variant
WT

AlphaFold metrics visual

Confident backbone model

79.6

390 residues / min 36.41 / max 97.88 / source alphafold db

PAE matrix for linked target
Very high 40.3% 157 residues / >=90
Confident 32.3% 126 residues / 70-89
Low 20.8% 81 residues / 50-69
Very low 6.7% 26 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 390 of 390 residues.

  • residues 1-36 / mean 47.64
  • residues 269-291 / mean 54.88
  • residues 92-104 / mean 57.73
  • residues 240-252 / mean 60.56
proof debt register

Visible limits, not hidden cleanup.

47%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:2b256ce1-1cc7-4664-a379-b78043fbc8eb -> fold:5e9af484-cf6c-4cf9-bcac-e63554c47269 folds_to / B / 0.796

what it supports

measured by AlphaFold confidence context fold:5e9af484-cf6c-4cf9-bcac-e63554c47269 -> alphafold_metric:5e9af484-cf6c-4cf9-bcac-e63554c47269 measured_by / B / 0.796
evidence finding attached fold:5e9af484-cf6c-4cf9-bcac-e63554c47269 -> finding:79f9795f-b38f-4fda-8a8e-07253e53bbde supports / C / 0.6
timeline records state change fold:5e9af484-cf6c-4cf9-bcac-e63554c47269 -> timeline_event:21 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.