Peptide RX

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proof receipt / target

TGFB1

Transforming growth factor beta-1

grade B status recovery receipt 4fca5211c085 proof 33%

what this node claims

TGFB1

Transforming growth factor beta-1

Open source surface

vertical proof spine

  1. 01 TGFB1 target / grade B / 70% 1 debt
  2. 02 Tendon-Homing TGFB1 Latency Mimetic idea / grade C / 55%
  3. 03 TGFB1 WT fold / grade B / 64% 2 debt

evidence / risk instrument

44%
thin proof
structure evidence gates risk export lineage 44
low debt pressure 21%
28%structuredebt
pLDDT pending
78%evidenceusable
grade B
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
33%lineagedebt
incomplete spine

proof completeness

33% missing alphafold_metric, candidate, finding, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

binding partners
    context annotations
    0
    family
    cytokine
    functional sites
      gene symbol
      TGFB1
      go terms
        uniprot
        P01137

        AlphaFold metrics visual

        Confident backbone model

        79.6

        390 residues / min 36.41 / max 97.88 / source alphafold db

        PAE matrix for linked target
        Very high 40.3% 157 residues / >=90
        Confident 32.3% 126 residues / 70-89
        Low 20.8% 81 residues / 50-69
        Very low 6.7% 26 residues / <50

        usable fold context with explicit model-confidence limits

        Near-complete coverage / observed 390 of 390 residues.

        • residues 1-36 / mean 47.64
        • residues 269-291 / mean 54.88
        • residues 92-104 / mean 57.73
        • residues 240-252 / mean 60.56
        proof debt register

        Visible limits, not hidden cleanup.

        21%

        Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

        medium missing functional-site annotations link target annotation, GO term, or binding-site context
        low computational-only status add independent evidence, challenge result, or witness review before strengthening
        medium no candidate yet leave visible until a stronger public receipt resolves it

        weakness and challenge edges

        What would stop this from becoming stronger.

        debt severity export claim strength next proof needed
        missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context
        computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
        no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it

        what supports it

        idea names target idea:3f9b2696-6be6-4c18-b678-87f5deba2f01 -> target:2b256ce1-1cc7-4664-a379-b78043fbc8eb targets / C / 0.44

        what it supports

        target has structure prediction target:2b256ce1-1cc7-4664-a379-b78043fbc8eb -> fold:5e9af484-cf6c-4cf9-bcac-e63554c47269 folds_to / B / 0.796

        Research-use boundary

        This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.