LEPR

Leptin receptor / UniProt P48357

Fold Report v1

Model confidence, target context, and design-readiness state.

This page binds the structure viewer to AlphaFold confidence data, agent findings, redacted candidate state, and non-clinical evidence limits so every fold is inspectable before it moves into a dossier.

Structure: alphafold-cdn pLDDT: alphafold db Coverage: 100.0% PAE: AlphaFold DB Candidates: 0 Findings: 1

Mean pLDDT 66.02 Low-confidence regions present

Residues 1165 per-residue parsed

Coverage 100.0% 1165/1165 residues

Evidence refs 1 agent-linked items

01 / Structure

AlphaFold v6 / streamed through the structure proxy / drag to rotate / scroll to zoom

02 / Per-residue confidence

1165 residues - very high (>90) confident (70-90) low (50-70) very low (<50)

03 / AlphaFold metrics

Reference prediction from the AlphaFold Protein Structure Database: predicted aligned error (PAE) plus per-position model confidence.

Predicted aligned error

Blue regions imply stronger relative-position confidence. Red off-diagonal regions signal domain-orientation uncertainty.

Predicted lDDT per position

1165 residues / mean 66.02 / min 20.67 / max 96.69

Very high 20.9% 243 residues / >=90

Confident 36.7% 427 residues / 70-89

Low 9.7% 113 residues / 50-69

Very low 32.8% 382 residues / <50

Coverage

Near-complete coverage: 1165 observed of 1165 residues.

Low-confidence intervals

res 864-1165 / mean 32.53 res 38-88 / mean 33.99 res 91-125 / mean 42.48 res 1-32 / mean 48.83

UniProt P48357 / open in AlphaFold DB

04 / Target context

Biological lane

metabolic

Family

cytokine_R

Pocket modes

ppi

Indication tags

satiety, obesity

Functional sites

Functional-site annotations are not cached for this target yet.

Binding partners

Binding-partner context is not cached for this target yet.

Gene ontology

GO terms are not cached for this target yet.

Residue-level functional sites, binding partners, and ontology tags are ready for ingestion but not cached for this fold yet.

Fold stats

Gene	LEPR
Length	1165 aa
pLDDT mean	66.02
Confidence	66.02%
pLDDT source	alphafold db
Model state	Low-confidence regions present
Status	complete
Lane	metabolic

Research-use only. Structure confidence is not biological validation; it is a model-quality receipt for downstream evidence grading.

Markdown export Proof spine Learning loop

Proof spine

This fold has a Claim Graph receipt linking target context, AlphaFold metrics, candidate design state, evidence findings, and exports where those records exist.

How this could be wrong

computational-only status low-confidence AlphaFold regions missing functional-site annotations no candidate yet

Candidate peptides (0)

Sequences redacted under public scope.

No candidates designed for this fold yet.

Agent findings (1)

literature C 05-01 21:04

Initial digest — LEPR

AlphaFold v6 prediction landed for **LEPR** (Leptin receptor). UniProt accession: `P48357`. Lane: `metabolic`. Mean per-residue pLDDT: **66.02**. JAK/STAT-coup...