HTR2A

Serotonin receptor 5-HT2A / UniProt P28223

Fold Report v1

Model confidence, target context, and design-readiness state.

This page binds the structure viewer to AlphaFold confidence data, agent findings, redacted candidate state, and non-clinical evidence limits so every fold is inspectable before it moves into a dossier.

Structure: alphafold-cdn pLDDT: alphafold db Coverage: 100.0% PAE: AlphaFold DB Candidates: 0 Findings: 1

Mean pLDDT 73.74 Confident backbone model

Residues 471 per-residue parsed

Coverage 100.0% 471/471 residues

Evidence refs 1 agent-linked items

01 / Structure

AlphaFold v6 / streamed through the structure proxy / drag to rotate / scroll to zoom

02 / Per-residue confidence

471 residues - very high (>90) confident (70-90) low (50-70) very low (<50)

03 / AlphaFold metrics

Reference prediction from the AlphaFold Protein Structure Database: predicted aligned error (PAE) plus per-position model confidence.

Predicted aligned error

Blue regions imply stronger relative-position confidence. Red off-diagonal regions signal domain-orientation uncertainty.

Predicted lDDT per position

471 residues / mean 73.74 / min 26.22 / max 98.62

Very high 50.7% 239 residues / >=90

Confident 10.6% 50 residues / 70-89

Low 11.3% 53 residues / 50-69

Very low 27.4% 129 residues / <50

Coverage

Near-complete coverage: 471 observed of 471 residues.

Low-confidence intervals

res 1-72 / mean 39.17 res 401-471 / mean 43.53 res 278-310 / mean 47.07 res 182-187 / mean 63.99

UniProt P28223 / open in AlphaFold DB

04 / Target context

Biological lane

cognitive

Family

GPCR_class_A

Pocket modes

ortho, allo

Indication tags

plasticity, mood, perception

Functional sites

Functional-site annotations are not cached for this target yet.

Binding partners

Binding-partner context is not cached for this target yet.

Gene ontology

GO terms are not cached for this target yet.

Residue-level functional sites, binding partners, and ontology tags are ready for ingestion but not cached for this fold yet.

Fold stats

Gene	HTR2A
Length	471 aa
pLDDT mean	73.74
Confidence	73.74%
pLDDT source	alphafold db
Model state	Confident backbone model
Status	complete
Lane	cognitive

Research-use only. Structure confidence is not biological validation; it is a model-quality receipt for downstream evidence grading.

Markdown export Proof spine Learning loop

Proof spine

This fold has a Claim Graph receipt linking target context, AlphaFold metrics, candidate design state, evidence findings, and exports where those records exist.

How this could be wrong

computational-only status low-confidence AlphaFold regions missing functional-site annotations no candidate yet

Candidate peptides (0)

Sequences redacted under public scope.

No candidates designed for this fold yet.

Agent findings (1)

literature C 05-01 21:04

Initial digest — HTR2A

AlphaFold v6 prediction landed for **HTR2A** (Serotonin receptor 5-HT2A). UniProt accession: `P28223`. Lane: `cognitive`. Mean per-residue pLDDT: **73.74**. Bi...