Peptide RX

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proof receipt / fold

HTR2A WT

Structure prediction with public confidence context.

grade B status complete receipt f2838399be44 proof 67%

what this node claims

HTR2A WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 HTR2A WT fold / grade B / 62% 2 debt
  2. 02 AlphaFold metrics / HTR2A alphafold metric / grade B / 70% 1 debt
  3. 03 Initial digest — HTR2A finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 HTR2A target / grade B / 70% 1 debt

evidence / risk instrument

49%
thin proof
structure evidence gates risk export lineage 49
visible debt pressure 47%
74%structureusable
pLDDT 73.74
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
confident
confidence pct
73.74
coverage available
false
gene
HTR2A
has structure
true
pae available
false
plddt avg
73.74
sequence length
0
variant
WT

AlphaFold metrics visual

Confident backbone model

73.7

471 residues / min 26.22 / max 98.62 / source alphafold db

PAE matrix for linked target
Very high 50.7% 239 residues / >=90
Confident 10.6% 50 residues / 70-89
Low 11.3% 53 residues / 50-69
Very low 27.4% 129 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 471 of 471 residues.

  • residues 1-72 / mean 39.17
  • residues 401-471 / mean 43.53
  • residues 278-310 / mean 47.07
  • residues 182-187 / mean 63.99
proof debt register

Visible limits, not hidden cleanup.

47%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:1f11cb52-b6a9-4c8f-8ed3-23cf680b9477 -> fold:7021e13f-876c-4639-a9fb-3ae71e1847b4 folds_to / B / 0.737

what it supports

measured by AlphaFold confidence context fold:7021e13f-876c-4639-a9fb-3ae71e1847b4 -> alphafold_metric:7021e13f-876c-4639-a9fb-3ae71e1847b4 measured_by / B / 0.737
evidence finding attached fold:7021e13f-876c-4639-a9fb-3ae71e1847b4 -> finding:b1c06e84-44d6-4ae0-82b3-b67bdbe78036 supports / C / 0.6
timeline records state change fold:7021e13f-876c-4639-a9fb-3ae71e1847b4 -> timeline_event:24 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.