Initial digest — HTR2A receipt

what this node claims

Initial digest — HTR2A

AlphaFold v6 prediction landed for **HTR2A** (Serotonin receptor 5-HT2A). UniProt accession: `P28223`. Lane: `cognitive`. Mean per-residue pLDDT: **73.74**. Biased agonism — separating plasticity from hallucinatory si...

Open source surface

vertical proof spine

evidence / risk instrument

39%

thin proof

low debt pressure 29%

28%structuredebt

pLDDT pending

55%evidencethin

grade C

0%gatesdebt

0/5 gates

100%riskstrong

0 hard flags

22%exportdebt

no export

33%lineagedebt

incomplete spine

proof completeness

33% missing target, alphafold_metric, candidate, export

01 target
02 fold
03 alphafold metric
04 candidate
05 finding
06 export

Metrics and receipt inputs

confidence: 0.6
evidence refs: 1

AlphaFold metrics visual

Confident backbone model

73.7

471 residues / min 26.22 / max 98.62 / source alphafold db

Very high 50.7% 239 residues / >=90

Confident 10.6% 50 residues / 70-89

Low 11.3% 53 residues / 50-69

Very low 27.4% 129 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 471 of 471 residues.

residues 1-72 / mean 39.17
residues 401-471 / mean 43.53
residues 278-310 / mean 47.07
residues 182-187 / mean 63.99

proof debt register

Visible limits, not hidden cleanup.

29%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

high low evidence grade attach graded finding with source-linked evidence

low computational-only status add independent evidence, challenge result, or witness review before strengthening

medium no candidate yet leave visible until a stronger public receipt resolves it

Initial digest — HTR2A