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TLR4

Toll-like receptor 4 / UniProt O00206

Fold Report v1

Model confidence, target context, and design-readiness state.

This page binds the structure viewer to AlphaFold confidence data, agent findings, redacted candidate state, and non-clinical evidence limits so every fold is inspectable before it moves into a dossier.

Structure: alphafold-cdn pLDDT: alphafold db Coverage: 100.0% PAE: AlphaFold DB Candidates: 0 Findings: 1

Mean pLDDT 89.2 Confident backbone model

Residues 839 per-residue parsed

Coverage 100.0% 839/839 residues

Evidence refs 1 agent-linked items

01 / Structure

AlphaFold v6 / streamed through the structure proxy / drag to rotate / scroll to zoom

02 / Per-residue confidence

839 residues - very high (>90) confident (70-90) low (50-70) very low (<50)

03 / AlphaFold metrics

Reference prediction from the AlphaFold Protein Structure Database: predicted aligned error (PAE) plus per-position model confidence.

Predicted aligned error

Blue regions imply stronger relative-position confidence. Red off-diagonal regions signal domain-orientation uncertainty.

Predicted lDDT per position

839 residues / mean 89.2 / min 28.11 / max 98.94

Very high 71.6% 601 residues / >=90

Confident 18.5% 155 residues / 70-89

Low 4.4% 37 residues / 50-69

Very low 5.5% 46 residues / <50

Coverage

Near-complete coverage: 839 observed of 839 residues.

Low-confidence intervals

res 1-27 / mean 41.1 res 818-839 / mean 39.07 res 656-672 / mean 58.09 res 627-632 / mean 62.26

UniProt O00206 / open in AlphaFold DB

04 / Target context

Biological lane

immune resilience

Family

pattern_recognition_R

Pocket modes

ppi

Indication tags

innate_immunity, vaccine_adjuvant

Functional sites

Functional-site annotations are not cached for this target yet.

Binding partners

Binding-partner context is not cached for this target yet.

Gene ontology

GO terms are not cached for this target yet.

Residue-level functional sites, binding partners, and ontology tags are ready for ingestion but not cached for this fold yet.

Fold stats

Gene	TLR4
Length	839 aa
pLDDT mean	89.20
Confidence	89.20%
pLDDT source	alphafold db
Model state	Confident backbone model
Status	complete
Lane	immune resilience

Research-use only. Structure confidence is not biological validation; it is a model-quality receipt for downstream evidence grading.

Markdown export Proof spine Learning loop

Proof spine

This fold has a Claim Graph receipt linking target context, AlphaFold metrics, candidate design state, evidence findings, and exports where those records exist.

How this could be wrong

computational-only status low-confidence AlphaFold regions missing functional-site annotations no candidate yet

Candidate peptides (0)

Sequences redacted under public scope.

No candidates designed for this fold yet.

Agent findings (1)

literature C 05-01 21:04

Initial digest — TLR4

AlphaFold v6 prediction landed for **TLR4** (Toll-like receptor 4). UniProt accession: `O00206`. Lane: `immune_resilience`. Mean per-residue pLDDT: **89.2**. A...