GRIN2B

NMDA receptor subunit NR2B / UniProt Q13224

Fold Report v1

Model confidence, target context, and design-readiness state.

This page binds the structure viewer to AlphaFold confidence data, agent findings, redacted candidate state, and non-clinical evidence limits so every fold is inspectable before it moves into a dossier.

Structure: alphafold-cdn pLDDT: alphafold db Coverage: 100.0% PAE: AlphaFold DB Candidates: 0 Findings: 1

Mean pLDDT 60.7 Low-confidence regions present

Residues 1484 per-residue parsed

Coverage 100.0% 1484/1484 residues

Evidence refs 1 agent-linked items

01 / Structure

AlphaFold v6 / streamed through the structure proxy / drag to rotate / scroll to zoom

02 / Per-residue confidence

1484 residues - very high (>90) confident (70-90) low (50-70) very low (<50)

03 / AlphaFold metrics

Reference prediction from the AlphaFold Protein Structure Database: predicted aligned error (PAE) plus per-position model confidence.

Predicted aligned error

Blue regions imply stronger relative-position confidence. Red off-diagonal regions signal domain-orientation uncertainty.

Predicted lDDT per position

1484 residues / mean 60.7 / min 24.03 / max 96.0

Very high 17.8% 264 residues / >=90

Confident 29.2% 434 residues / 70-89

Low 8.8% 131 residues / 50-69

Very low 44.1% 655 residues / <50

Coverage

Near-complete coverage: 1484 observed of 1484 residues.

Low-confidence intervals

res 845-1484 / mean 33.4 res 1-32 / mean 42.87 res 581-600 / mean 52.73 res 44-58 / mean 60.07

UniProt Q13224 / open in AlphaFold DB

04 / Target context

Biological lane

cognitive

Family

ligand_gated_ion_channel

Pocket modes

allo

Indication tags

LTP, memory, depression

Functional sites

Functional-site annotations are not cached for this target yet.

Binding partners

Binding-partner context is not cached for this target yet.

Gene ontology

GO terms are not cached for this target yet.

Residue-level functional sites, binding partners, and ontology tags are ready for ingestion but not cached for this fold yet.

Fold stats

Gene	GRIN2B
Length	1484 aa
pLDDT mean	60.70
Confidence	60.70%
pLDDT source	alphafold db
Model state	Low-confidence regions present
Status	complete
Lane	cognitive

Research-use only. Structure confidence is not biological validation; it is a model-quality receipt for downstream evidence grading.

Markdown export Proof spine Learning loop

Proof spine

This fold has a Claim Graph receipt linking target context, AlphaFold metrics, candidate design state, evidence findings, and exports where those records exist.

How this could be wrong

computational-only status low-confidence AlphaFold regions missing functional-site annotations no candidate yet

Candidate peptides (0)

Sequences redacted under public scope.

No candidates designed for this fold yet.

Agent findings (1)

literature C 05-01 21:04

Initial digest — GRIN2B

AlphaFold v6 prediction landed for **GRIN2B** (NMDA receptor subunit NR2B). UniProt accession: `Q13224`. Lane: `cognitive`. Mean per-residue pLDDT: **60.7**. A...