Peptide RX

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proof receipt / finding

Initial digest — TERT

AlphaFold v6 prediction landed for **TERT** (Telomerase reverse transcriptase). UniProt accession: `O14746`. Lane: `longevity`. Mean per-residue pLDDT: **80.2**. Activator design — exquisite tissue specificity require...

grade C status literature receipt c56860c00acb proof 33%

what this node claims

Initial digest — TERT

AlphaFold v6 prediction landed for **TERT** (Telomerase reverse transcriptase). UniProt accession: `O14746`. Lane: `longevity`. Mean per-residue pLDDT: **80.2**. Activator design — exquisite tissue specificity require...

evidence / risk instrument

39%
thin proof
structure evidence gates risk export lineage 39
low debt pressure 29%
28%structuredebt
pLDDT pending
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
33%lineagedebt
incomplete spine

proof completeness

33% missing target, alphafold_metric, candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence
0.6
evidence refs
1

AlphaFold metrics visual

Confident backbone model

80.2

1132 residues / min 21.31 / max 98.56 / source alphafold db

PAE matrix for linked target
Very high 58.3% 660 residues / >=90
Confident 21.1% 239 residues / 70-89
Low 3.9% 44 residues / 50-69
Very low 16.7% 189 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 1132 of 1132 residues.

  • residues 179-323 / mean 28.06
  • residues 417-443 / mean 38.37
  • residues 636-654 / mean 47.04
  • residues 367-380 / mean 46.25
proof debt register

Visible limits, not hidden cleanup.

29%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

high low evidence grade attach graded finding with source-linked evidence
low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
low evidence grade high blocks weakens attach graded finding with source-linked evidence
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it

what supports it

evidence finding attached fold:e7169022-fda3-45ba-a266-850753926013 -> finding:4f371dc5-9102-435b-ad6d-95161f7c964d supports / C / 0.6

what it supports

No downstream proof edge yet.

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.