Initial digest — TrkB receipt

what this node claims

Initial digest — TrkB

AlphaFold v6 prediction landed for **TrkB** (Tropomyosin receptor kinase B (BDNF receptor)). UniProt accession: `Q16620`. Lane: `cognitive`. Mean per-residue pLDDT: **76.97**. BDNF mimetics; selectivity vs TrkA/C impo...

Open source surface

vertical proof spine

evidence / risk instrument

39%

thin proof

low debt pressure 29%

28%structuredebt

pLDDT pending

55%evidencethin

grade C

0%gatesdebt

0/5 gates

100%riskstrong

0 hard flags

22%exportdebt

no export

33%lineagedebt

incomplete spine

proof completeness

33% missing target, alphafold_metric, candidate, export

01 target
02 fold
03 alphafold metric
04 candidate
05 finding
06 export

Metrics and receipt inputs

confidence: 0.6
evidence refs: 1

AlphaFold metrics visual

Confident backbone model

77.0

822 residues / min 23.52 / max 98.38 / source alphafold db

Very high 44.3% 364 residues / >=90

Confident 29.6% 243 residues / 70-89

Low 7.3% 60 residues / 50-69

Very low 18.9% 155 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 822 of 822 residues.

residues 455-528 / mean 32.1
residues 382-435 / mean 38.95
residues 1-31 / mean 36.34
residues 694-703 / mean 57.27

proof debt register

Visible limits, not hidden cleanup.

29%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

high low evidence grade attach graded finding with source-linked evidence

low computational-only status add independent evidence, challenge result, or witness review before strengthening

medium no candidate yet leave visible until a stronger public receipt resolves it

Initial digest — TrkB