Initial digest — GRIN2B receipt

what this node claims

Initial digest — GRIN2B

AlphaFold v6 prediction landed for **GRIN2B** (NMDA receptor subunit NR2B). UniProt accession: `Q13224`. Lane: `cognitive`. Mean per-residue pLDDT: **60.7**. Allosteric modulator design; orthosteric NMDA carries risk.

Open source surface

vertical proof spine

evidence / risk instrument

38%

thin proof

low debt pressure 32%

28%structuredebt

pLDDT pending

55%evidencethin

grade C

0%gatesdebt

0/5 gates

100%riskstrong

0 hard flags

22%exportdebt

no export

33%lineagedebt

incomplete spine

proof completeness

33% missing target, alphafold_metric, candidate, export

01 target
02 fold
03 alphafold metric
04 candidate
05 finding
06 export

Metrics and receipt inputs

confidence: 0.6
evidence refs: 1

AlphaFold metrics visual

Low-confidence regions present

60.7

1484 residues / min 24.03 / max 96.0 / source alphafold db

Very high 17.8% 264 residues / >=90

Confident 29.2% 434 residues / 70-89

Low 8.8% 131 residues / 50-69

Very low 44.1% 655 residues / <50

weak structural context; downstream claims should be conservative

Near-complete coverage / observed 1484 of 1484 residues.

residues 845-1484 / mean 33.4
residues 1-32 / mean 42.87
residues 581-600 / mean 52.73
residues 44-58 / mean 60.07

proof debt register

Visible limits, not hidden cleanup.

32%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

high low evidence grade attach graded finding with source-linked evidence

low computational-only status add independent evidence, challenge result, or witness review before strengthening

low low-confidence AlphaFold regions likely attach pLDDT series, PAE matrix, or coverage evidence

medium no candidate yet leave visible until a stronger public receipt resolves it

Initial digest — GRIN2B