Initial digest — LEPR receipt

what this node claims

Initial digest — LEPR

AlphaFold v6 prediction landed for **LEPR** (Leptin receptor). UniProt accession: `P48357`. Lane: `metabolic`. Mean per-residue pLDDT: **66.02**. JAK/STAT-coupled cytokine receptor.

Open source surface

vertical proof spine

evidence / risk instrument

38%

thin proof

low debt pressure 32%

28%structuredebt

pLDDT pending

55%evidencethin

grade C

0%gatesdebt

0/5 gates

100%riskstrong

0 hard flags

22%exportdebt

no export

33%lineagedebt

incomplete spine

proof completeness

33% missing target, alphafold_metric, candidate, export

01 target
02 fold
03 alphafold metric
04 candidate
05 finding
06 export

Metrics and receipt inputs

confidence: 0.6
evidence refs: 1

AlphaFold metrics visual

Low-confidence regions present

66.0

1165 residues / min 20.67 / max 96.69 / source alphafold db

Very high 20.9% 243 residues / >=90

Confident 36.7% 427 residues / 70-89

Low 9.7% 113 residues / 50-69

Very low 32.8% 382 residues / <50

weak structural context; downstream claims should be conservative

Near-complete coverage / observed 1165 of 1165 residues.

residues 864-1165 / mean 32.53
residues 38-88 / mean 33.99
residues 91-125 / mean 42.48
residues 1-32 / mean 48.83

proof debt register

Visible limits, not hidden cleanup.

32%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

high low evidence grade attach graded finding with source-linked evidence

low computational-only status add independent evidence, challenge result, or witness review before strengthening

low low-confidence AlphaFold regions likely attach pLDDT series, PAE matrix, or coverage evidence

medium no candidate yet leave visible until a stronger public receipt resolves it

Initial digest — LEPR