Initial digest — FOXO3 receipt

what this node claims

Initial digest — FOXO3

AlphaFold v6 prediction landed for **FOXO3** (Forkhead box O3). UniProt accession: `O43524`. Lane: `longevity`. Mean per-residue pLDDT: **50.66**. 14-3-3 PPI disruptor / nuclear-localization stabilizer wedge.

Open source surface

vertical proof spine

evidence / risk instrument

38%

thin proof

low debt pressure 32%

28%structuredebt

pLDDT pending

55%evidencethin

grade C

0%gatesdebt

0/5 gates

100%riskstrong

0 hard flags

22%exportdebt

no export

33%lineagedebt

incomplete spine

proof completeness

33% missing target, alphafold_metric, candidate, export

01 target
02 fold
03 alphafold metric
04 candidate
05 finding
06 export

Metrics and receipt inputs

confidence: 0.6
evidence refs: 1

AlphaFold metrics visual

Low-confidence regions present

50.7

673 residues / min 30.38 / max 97.69 / source alphafold db

Very high 9.2% 62 residues / >=90

Confident 4.2% 28 residues / 70-89

Low 17.5% 118 residues / 50-69

Very low 69.1% 465 residues / <50

weak structural context; downstream claims should be conservative

Near-complete coverage / observed 673 of 673 residues.

residues 240-622 / mean 43.05
residues 1-153 / mean 47.37
residues 630-673 / mean 45.99
residues 201-202 / mean 64.41

proof debt register

Visible limits, not hidden cleanup.

32%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

high low evidence grade attach graded finding with source-linked evidence

low computational-only status add independent evidence, challenge result, or witness review before strengthening

low low-confidence AlphaFold regions likely attach pLDDT series, PAE matrix, or coverage evidence

medium no candidate yet leave visible until a stronger public receipt resolves it

Initial digest — FOXO3