Initial digest — SIRT1 receipt

what this node claims

Initial digest — SIRT1

AlphaFold v6 prediction landed for **SIRT1** (NAD-dependent deacetylase sirtuin-1). UniProt accession: `Q96EB6`. Lane: `longevity`. Mean per-residue pLDDT: **65.02**. STAC-class allosteric activator wedge.

Open source surface

vertical proof spine

evidence / risk instrument

38%

thin proof

low debt pressure 32%

28%structuredebt

pLDDT pending

55%evidencethin

grade C

0%gatesdebt

0/5 gates

100%riskstrong

0 hard flags

22%exportdebt

no export

33%lineagedebt

incomplete spine

proof completeness

33% missing target, alphafold_metric, candidate, export

01 target
02 fold
03 alphafold metric
04 candidate
05 finding
06 export

Metrics and receipt inputs

confidence: 0.6
evidence refs: 1

AlphaFold metrics visual

Low-confidence regions present

65.0

747 residues / min 24.66 / max 98.88 / source alphafold db

Very high 36.9% 276 residues / >=90

Confident 13.0% 97 residues / 70-89

Low 3.5% 26 residues / 50-69

Very low 46.6% 348 residues / <50

weak structural context; downstream claims should be conservative

Near-complete coverage / observed 747 of 747 residues.

residues 1-148 / mean 37.74
residues 517-630 / mean 36.16
residues 660-747 / mean 37.45
residues 155-177 / mean 48.56

proof debt register

Visible limits, not hidden cleanup.

32%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

high low evidence grade attach graded finding with source-linked evidence

low computational-only status add independent evidence, challenge result, or witness review before strengthening

low low-confidence AlphaFold regions likely attach pLDDT series, PAE matrix, or coverage evidence

medium no candidate yet leave visible until a stronger public receipt resolves it

Initial digest — SIRT1