Peptide RX

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proof receipt / finding

Initial digest — OX2R

AlphaFold v6 prediction landed for **OX2R** (Orexin receptor type 2). UniProt accession: `O43614`. Lane: `sleep_circadian`. Mean per-residue pLDDT: **78.96**. Agonist wedge for narcolepsy; antagonist (DORA) wedge for...

grade C status literature receipt a5df3ba73a29 proof 33%

what this node claims

Initial digest — OX2R

AlphaFold v6 prediction landed for **OX2R** (Orexin receptor type 2). UniProt accession: `O43614`. Lane: `sleep_circadian`. Mean per-residue pLDDT: **78.96**. Agonist wedge for narcolepsy; antagonist (DORA) wedge for...

evidence / risk instrument

39%
thin proof
structure evidence gates risk export lineage 39
low debt pressure 29%
28%structuredebt
pLDDT pending
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
33%lineagedebt
incomplete spine

proof completeness

33% missing target, alphafold_metric, candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence
0.6
evidence refs
1

AlphaFold metrics visual

Confident backbone model

79.0

444 residues / min 32.28 / max 98.69 / source alphafold db

PAE matrix for linked target
Very high 52.0% 231 residues / >=90
Confident 16.7% 74 residues / 70-89
Low 14.9% 66 residues / 50-69
Very low 16.4% 73 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 444 of 444 residues.

  • residues 384-444 / mean 49.88
  • residues 1-34 / mean 41.73
  • residues 253-286 / mean 50.91
  • residues 197-206 / mean 57.07
proof debt register

Visible limits, not hidden cleanup.

29%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

high low evidence grade attach graded finding with source-linked evidence
low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
low evidence grade high blocks weakens attach graded finding with source-linked evidence
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it

what supports it

evidence finding attached fold:05b968cf-a48c-4000-8e51-b740fcffcba5 -> finding:f2b67c72-79af-4325-86d2-353c3e5c1caf supports / C / 0.6

what it supports

No downstream proof edge yet.

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.