Initial digest — TLR4 receipt

what this node claims

Initial digest — TLR4

AlphaFold v6 prediction landed for **TLR4** (Toll-like receptor 4). UniProt accession: `O00206`. Lane: `immune_resilience`. Mean per-residue pLDDT: **89.2**. Agonist (adjuvant) and antagonist (sepsis) wedges both inte...

Open source surface

vertical proof spine

evidence / risk instrument

39%

thin proof

low debt pressure 29%

28%structuredebt

pLDDT pending

55%evidencethin

grade C

0%gatesdebt

0/5 gates

100%riskstrong

0 hard flags

22%exportdebt

no export

33%lineagedebt

incomplete spine

proof completeness

33% missing target, alphafold_metric, candidate, export

01 target
02 fold
03 alphafold metric
04 candidate
05 finding
06 export

Metrics and receipt inputs

confidence: 0.6
evidence refs: 1

AlphaFold metrics visual

Confident backbone model

89.2

839 residues / min 28.11 / max 98.94 / source alphafold db

Very high 71.6% 601 residues / >=90

Confident 18.5% 155 residues / 70-89

Low 4.4% 37 residues / 50-69

Very low 5.5% 46 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 839 of 839 residues.

residues 1-27 / mean 41.1
residues 818-839 / mean 39.07
residues 656-672 / mean 58.09
residues 627-632 / mean 62.26

proof debt register

Visible limits, not hidden cleanup.

29%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

high low evidence grade attach graded finding with source-linked evidence

low computational-only status add independent evidence, challenge result, or witness review before strengthening

medium no candidate yet leave visible until a stronger public receipt resolves it

Initial digest — TLR4