Peptide RX

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proof receipt / fold

CXCR4 WT

Structure prediction with public confidence context.

grade B status complete receipt abac57d4ee58 proof 67%

what this node claims

CXCR4 WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 CXCR4 WT fold / grade B / 66% 2 debt
  2. 02 AlphaFold metrics / CXCR4 alphafold metric / grade B / 74% 1 debt
  3. 03 Initial digest — CXCR4-TMSB4-axis finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 CXCR4-TMSB4-axis target / grade B / 70% 1 debt

evidence / risk instrument

50%
thin proof
structure evidence gates risk export lineage 50
visible debt pressure 47%
82%structurestrong
pLDDT 82.26
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
confident
confidence pct
82.26
coverage available
false
gene
CXCR4
has structure
true
pae available
false
plddt avg
82.26
sequence length
0
variant
WT

AlphaFold metrics visual

Confident backbone model

82.3

352 residues / min 31.7 / max 98.5 / source alphafold db

PAE matrix for linked target
Very high 57.4% 202 residues / >=90
Confident 21.6% 76 residues / 70-89
Low 8.2% 29 residues / 50-69
Very low 12.8% 45 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 352 of 352 residues.

  • residues 320-352 / mean 48.4
  • residues 1-26 / mean 39.48
  • residues 304-310 / mean 63.5
  • residues 29-34 / mean 63.78
proof debt register

Visible limits, not hidden cleanup.

47%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:529e55fe-c9ac-4db1-adcc-8cc266ab4833 -> fold:244554f9-4d1c-4942-abbc-a8c18e6783f1 folds_to / B / 0.823

what it supports

measured by AlphaFold confidence context fold:244554f9-4d1c-4942-abbc-a8c18e6783f1 -> alphafold_metric:244554f9-4d1c-4942-abbc-a8c18e6783f1 measured_by / B / 0.823
evidence finding attached fold:244554f9-4d1c-4942-abbc-a8c18e6783f1 -> finding:ec59bc0f-f4e0-4b7a-b2f3-9276878594c3 supports / C / 0.6
timeline records state change fold:244554f9-4d1c-4942-abbc-a8c18e6783f1 -> timeline_event:7 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.