Peptide RX

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proof receipt / fold

GLP1R WT

Structure prediction with public confidence context.

grade B status complete receipt 79ddeb2bd4d8 proof 67%

what this node claims

GLP1R WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 GLP1R WT fold / grade B / 66% 2 debt
  2. 02 AlphaFold metrics / GLP1R alphafold metric / grade B / 74% 1 debt
  3. 03 Initial digest — GLP-1R finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 GLP-1R target / grade B / 70% 1 debt

evidence / risk instrument

50%
thin proof
structure evidence gates risk export lineage 50
visible debt pressure 47%
82%structurestrong
pLDDT 81.51
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
confident
confidence pct
81.51
coverage available
false
gene
GLP1R
has structure
true
pae available
false
plddt avg
81.51
sequence length
0
variant
WT

AlphaFold metrics visual

Confident backbone model

81.5

463 residues / min 27.03 / max 98.25 / source alphafold db

PAE matrix for linked target
Very high 47.1% 218 residues / >=90
Confident 35.6% 165 residues / 70-89
Low 5.8% 27 residues / 50-69
Very low 11.4% 53 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 463 of 463 residues.

  • residues 432-463 / mean 43.36
  • residues 1-30 / mean 39.91
  • residues 130-137 / mean 55.76
  • residues 370-376 / mean 59.89
proof debt register

Visible limits, not hidden cleanup.

47%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:c6c265ea-7550-4914-a2ee-b295e4a1e476 -> fold:af1fb866-d507-4048-9c36-ba5b07a5d376 folds_to / B / 0.815

what it supports

measured by AlphaFold confidence context fold:af1fb866-d507-4048-9c36-ba5b07a5d376 -> alphafold_metric:af1fb866-d507-4048-9c36-ba5b07a5d376 measured_by / B / 0.815
evidence finding attached fold:af1fb866-d507-4048-9c36-ba5b07a5d376 -> finding:17c09277-b0b7-46aa-bcd1-1e42192040e0 supports / C / 0.6
timeline records state change fold:af1fb866-d507-4048-9c36-ba5b07a5d376 -> timeline_event:5 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.