Peptide RX

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proof receipt / target

AGRP

Agouti-related protein

grade B status metabolic receipt 5ec157849a87 proof 33%

what this node claims

AGRP

Agouti-related protein

Open source surface

vertical proof spine

  1. 01 AGRP target / grade B / 70% 1 debt
  2. 02 AGRP WT fold / grade B / 54% 3 debt

evidence / risk instrument

44%
thin proof
structure evidence gates risk export lineage 44
low debt pressure 24%
28%structuredebt
pLDDT pending
78%evidenceusable
grade B
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
33%lineagedebt
incomplete spine

proof completeness

33% missing alphafold_metric, candidate, finding, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

binding partners
    context annotations
    0
    family
    endogenous_peptide
    functional sites
      gene symbol
      AGRP
      go terms
        uniprot
        O00253

        AlphaFold metrics visual

        Low-confidence regions present

        69.5

        132 residues / min 35.16 / max 96.06 / source alphafold db

        PAE matrix for linked target
        Very high 21.2% 28 residues / >=90
        Confident 29.5% 39 residues / 70-89
        Low 27.3% 36 residues / 50-69
        Very low 22.0% 29 residues / <50

        weak structural context; downstream claims should be conservative

        Near-complete coverage / observed 132 of 132 residues.

        • residues 16-58 / mean 47.61
        • residues 75-85 / mean 60.44
        • residues 123-132 / mean 61.68
        • residues 1-1 / mean 65.25
        proof debt register

        Visible limits, not hidden cleanup.

        24%

        Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

        medium missing functional-site annotations link target annotation, GO term, or binding-site context
        low computational-only status add independent evidence, challenge result, or witness review before strengthening
        low low-confidence AlphaFold regions likely attach pLDDT series, PAE matrix, or coverage evidence
        medium no candidate yet leave visible until a stronger public receipt resolves it

        weakness and challenge edges

        What would stop this from becoming stronger.

        debt severity export claim strength next proof needed
        missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context
        computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
        low-confidence AlphaFold regions likely low visible watch attach pLDDT series, PAE matrix, or coverage evidence
        no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it

        what supports it

        No upstream proof edge yet.

        what it supports

        target has structure prediction target:c7f04fc6-ad61-4352-8ea0-d5518d266951 -> fold:46338df4-b8aa-490b-998d-19932ee18178 folds_to / B / 0.695

        Research-use boundary

        This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.