Peptide RX

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proof receipt / fold

AGRP WT

Structure prediction with public confidence context.

grade B status complete receipt 7168f9d7f2b4 proof 67%

what this node claims

AGRP WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 AGRP WT fold / grade B / 54% 3 debt
  2. 02 AlphaFold metrics / AGRP alphafold metric / grade B / 70% 1 debt
  3. 03 Initial digest — AGRP finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 AGRP target / grade B / 70% 1 debt

evidence / risk instrument

48%
thin proof
structure evidence gates risk export lineage 48
visible debt pressure 50%
70%structureusable
pLDDT 69.53
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
low
confidence pct
69.53
coverage available
false
gene
AGRP
has structure
true
pae available
false
plddt avg
69.53
sequence length
0
variant
WT

AlphaFold metrics visual

Low-confidence regions present

69.5

132 residues / min 35.16 / max 96.06 / source alphafold db

PAE matrix for linked target
Very high 21.2% 28 residues / >=90
Confident 29.5% 39 residues / 70-89
Low 27.3% 36 residues / 50-69
Very low 22.0% 29 residues / <50

weak structural context; downstream claims should be conservative

Near-complete coverage / observed 132 of 132 residues.

  • residues 16-58 / mean 47.61
  • residues 75-85 / mean 60.44
  • residues 123-132 / mean 61.68
  • residues 1-1 / mean 65.25
proof debt register

Visible limits, not hidden cleanup.

50%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
low low-confidence AlphaFold regions likely attach pLDDT series, PAE matrix, or coverage evidence
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
low-confidence AlphaFold regions likely low visible watch attach pLDDT series, PAE matrix, or coverage evidence
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:c7f04fc6-ad61-4352-8ea0-d5518d266951 -> fold:46338df4-b8aa-490b-998d-19932ee18178 folds_to / B / 0.695

what it supports

measured by AlphaFold confidence context fold:46338df4-b8aa-490b-998d-19932ee18178 -> alphafold_metric:46338df4-b8aa-490b-998d-19932ee18178 measured_by / B / 0.695
evidence finding attached fold:46338df4-b8aa-490b-998d-19932ee18178 -> finding:e161610a-0dfb-4a74-b0bd-7a1362733782 supports / C / 0.6
timeline records state change fold:46338df4-b8aa-490b-998d-19932ee18178 -> timeline_event:16 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.