Initial digest — AGRP receipt

what this node claims

Initial digest — AGRP

AlphaFold v6 prediction landed for **AGRP** (Agouti-related protein). UniProt accession: `O00253`. Lane: `metabolic`. Mean per-residue pLDDT: **69.53**. Endogenous MC4R inverse agonist; PPI design target.

Open source surface

vertical proof spine

evidence / risk instrument

38%

thin proof

low debt pressure 32%

28%structuredebt

pLDDT pending

55%evidencethin

grade C

0%gatesdebt

0/5 gates

100%riskstrong

0 hard flags

22%exportdebt

no export

33%lineagedebt

incomplete spine

proof completeness

33% missing target, alphafold_metric, candidate, export

01 target
02 fold
03 alphafold metric
04 candidate
05 finding
06 export

Metrics and receipt inputs

confidence: 0.6
evidence refs: 1

AlphaFold metrics visual

Low-confidence regions present

69.5

132 residues / min 35.16 / max 96.06 / source alphafold db

Very high 21.2% 28 residues / >=90

Confident 29.5% 39 residues / 70-89

Low 27.3% 36 residues / 50-69

Very low 22.0% 29 residues / <50

weak structural context; downstream claims should be conservative

Near-complete coverage / observed 132 of 132 residues.

residues 16-58 / mean 47.61
residues 75-85 / mean 60.44
residues 123-132 / mean 61.68
residues 1-1 / mean 65.25

proof debt register

Visible limits, not hidden cleanup.

32%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

high low evidence grade attach graded finding with source-linked evidence

low computational-only status add independent evidence, challenge result, or witness review before strengthening

low low-confidence AlphaFold regions likely attach pLDDT series, PAE matrix, or coverage evidence

medium no candidate yet leave visible until a stronger public receipt resolves it

Initial digest — AGRP