Peptide RX

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proof receipt / target

MC1R

Melanocortin-1 receptor

grade B status sexual_wellbeing receipt d0461e300d9d proof 33%

what this node claims

MC1R

Melanocortin-1 receptor

Open source surface

vertical proof spine

  1. 01 MC1R target / grade B / 70% 1 debt
  2. 02 Effect design run idea / grade C / 47% 1 debt
  3. 03 MC1R WT fold / grade B / 65% 2 debt

evidence / risk instrument

43%
thin proof
structure evidence gates risk export lineage 43
low debt pressure 30%
28%structuredebt
pLDDT pending
78%evidenceusable
grade B
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
33%lineagedebt
incomplete spine

proof completeness

33% missing alphafold_metric, candidate, finding, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

binding partners
    context annotations
    0
    family
    GPCR_class_A
    functional sites
      gene symbol
      MC1R
      go terms
        uniprot
        Q01726

        AlphaFold metrics visual

        Confident backbone model

        80.5

        317 residues / min 26.03 / max 98.38 / source alphafold db

        PAE matrix for linked target
        Very high 35.0% 111 residues / >=90
        Confident 47.0% 149 residues / 70-89
        Low 7.3% 23 residues / 50-69
        Very low 10.7% 34 residues / <50

        usable fold context with explicit model-confidence limits

        Near-complete coverage / observed 317 of 317 residues.

        • residues 1-34 / mean 40.89
        • residues 226-244 / mean 54.93
        • residues 316-317 / mean 60.66
        • residues 300-301 / mean 67.91
        proof debt register

        Visible limits, not hidden cleanup.

        30%

        Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

        medium missing functional-site annotations link target annotation, GO term, or binding-site context
        low computational-only status add independent evidence, challenge result, or witness review before strengthening
        medium no candidate yet leave visible until a stronger public receipt resolves it
        medium no candidate yet leave visible until a stronger public receipt resolves it

        weakness and challenge edges

        What would stop this from becoming stronger.

        debt severity export claim strength next proof needed
        missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context
        computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
        no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
        no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it

        what supports it

        effect run matched target idea:effect-run:38e488cc-f587-4906-8789-ccd3b14dd56d -> target:f1bed146-917d-4f21-8fb4-4c5f824113bb targets / C / 0.52

        what it supports

        target has structure prediction target:f1bed146-917d-4f21-8fb4-4c5f824113bb -> fold:baeb1fd3-d1a7-42ee-a6e7-f03328f9e748 folds_to / B / 0.805

        Research-use boundary

        This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.