Peptide RX

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proof receipt / fold

MC1R WT

Structure prediction with public confidence context.

grade B status complete receipt 5e3ff82f0058 proof 67%

what this node claims

MC1R WT

Structure prediction with public confidence context.

Open source surface

vertical proof spine

  1. 01 MC1R WT fold / grade B / 65% 2 debt
  2. 02 AlphaFold metrics / MC1R alphafold metric / grade B / 73% 1 debt
  3. 03 Initial digest — MC1R finding / grade C / 47% 1 debt
  4. 04 fold.complete timeline event / grade C / 55%
  5. 05 MC1R target / grade B / 70% 1 debt

evidence / risk instrument

50%
thin proof
structure evidence gates risk export lineage 50
visible debt pressure 47%
81%structurestrong
pLDDT 80.51
55%evidencethin
grade C
0%gatesdebt
0/5 gates
100%riskstrong
0 hard flags
22%exportdebt
no export
67%lineageusable
incomplete spine

proof completeness

67% missing candidate, export
  1. 01 target
  2. 02 fold
  3. 03 alphafold metric
  4. 04 candidate
  5. 05 finding
  6. 06 export

Metrics and receipt inputs

confidence band
confident
confidence pct
80.51
coverage available
false
gene
MC1R
has structure
true
pae available
false
plddt avg
80.51
sequence length
0
variant
WT

AlphaFold metrics visual

Confident backbone model

80.5

317 residues / min 26.03 / max 98.38 / source alphafold db

PAE matrix for linked target
Very high 35.0% 111 residues / >=90
Confident 47.0% 149 residues / 70-89
Low 7.3% 23 residues / 50-69
Very low 10.7% 34 residues / <50

usable fold context with explicit model-confidence limits

Near-complete coverage / observed 317 of 317 residues.

  • residues 1-34 / mean 40.89
  • residues 226-244 / mean 54.93
  • residues 316-317 / mean 60.66
  • residues 300-301 / mean 67.91
proof debt register

Visible limits, not hidden cleanup.

47%

Peptide RX keeps unresolved proof debt attached to the public receipt. Some debts should be resolved; redaction and research-use boundaries should stay visible.

low computational-only status add independent evidence, challenge result, or witness review before strengthening
medium no candidate yet leave visible until a stronger public receipt resolves it
medium missing PAE/context where AlphaFold DB is not linked attach pLDDT series, PAE matrix, or coverage evidence
high low evidence grade attach graded finding with source-linked evidence
medium missing functional-site annotations link target annotation, GO term, or binding-site context

weakness and challenge edges

What would stop this from becoming stronger.

debt severity export claim strength next proof needed
computational-only status low visible watch add independent evidence, challenge result, or witness review before strengthening
no candidate yet medium visible weakens leave visible until a stronger public receipt resolves it
missing PAE/context where AlphaFold DB is not linked medium visible weakens attach pLDDT series, PAE matrix, or coverage evidence
low evidence grade high blocks weakens attach graded finding with source-linked evidence
missing functional-site annotations medium visible weakens link target annotation, GO term, or binding-site context

what supports it

target has structure prediction target:f1bed146-917d-4f21-8fb4-4c5f824113bb -> fold:baeb1fd3-d1a7-42ee-a6e7-f03328f9e748 folds_to / B / 0.805

what it supports

measured by AlphaFold confidence context fold:baeb1fd3-d1a7-42ee-a6e7-f03328f9e748 -> alphafold_metric:baeb1fd3-d1a7-42ee-a6e7-f03328f9e748 measured_by / B / 0.805
evidence finding attached fold:baeb1fd3-d1a7-42ee-a6e7-f03328f9e748 -> finding:a4c9aafc-0d7a-4270-8f79-10189c5518c7 supports / C / 0.6
timeline records state change fold:baeb1fd3-d1a7-42ee-a6e7-f03328f9e748 -> timeline_event:33 records / C / 0.5

Research-use boundary

This receipt describes public computational research state. It does not expose raw candidate sequences and does not make a clinical claim.