ESR1

Estrogen receptor alpha / UniProt P03372

Fold Report v1

Model confidence, target context, and design-readiness state.

This page binds the structure viewer to AlphaFold confidence data, agent findings, redacted candidate state, and non-clinical evidence limits so every fold is inspectable before it moves into a dossier.

Structure: alphafold-cdn pLDDT: alphafold db Coverage: 100.0% PAE: AlphaFold DB Candidates: 0 Findings: 1

Mean pLDDT 66.43 Low-confidence regions present

Residues 595 per-residue parsed

Coverage 100.0% 595/595 residues

Evidence refs 1 agent-linked items

01 / Structure

AlphaFold v6 / streamed through the structure proxy / drag to rotate / scroll to zoom

02 / Per-residue confidence

595 residues - very high (>90) confident (70-90) low (50-70) very low (<50)

03 / AlphaFold metrics

Reference prediction from the AlphaFold Protein Structure Database: predicted aligned error (PAE) plus per-position model confidence.

Predicted aligned error

Blue regions imply stronger relative-position confidence. Red off-diagonal regions signal domain-orientation uncertainty.

Predicted lDDT per position

595 residues / mean 66.43 / min 26.55 / max 98.62

Very high 43.5% 259 residues / >=90

Confident 6.9% 41 residues / 70-89

Low 3.2% 19 residues / 50-69

Very low 46.4% 276 residues / <50

Coverage

Near-complete coverage: 595 observed of 595 residues.

Low-confidence intervals

res 1-180 / mean 36.06 res 254-304 / mean 40.24 res 549-595 / mean 38.21 res 457-472 / mean 53.24

UniProt P03372 / open in AlphaFold DB

04 / Target context

Biological lane

sexual wellbeing

Family

nuclear_receptor

Pocket modes

ortho, allo

Indication tags

hormone_replacement, bone, cognition

Functional sites

Functional-site annotations are not cached for this target yet.

Binding partners

Binding-partner context is not cached for this target yet.

Gene ontology

GO terms are not cached for this target yet.

Residue-level functional sites, binding partners, and ontology tags are ready for ingestion but not cached for this fold yet.

Fold stats

Gene	ESR1
Length	595 aa
pLDDT mean	66.43
Confidence	66.43%
pLDDT source	alphafold db
Model state	Low-confidence regions present
Status	complete
Lane	sexual wellbeing

Research-use only. Structure confidence is not biological validation; it is a model-quality receipt for downstream evidence grading.

Markdown export Proof spine Learning loop

Proof spine

This fold has a Claim Graph receipt linking target context, AlphaFold metrics, candidate design state, evidence findings, and exports where those records exist.

How this could be wrong

computational-only status low-confidence AlphaFold regions missing functional-site annotations no candidate yet

Candidate peptides (0)

Sequences redacted under public scope.

No candidates designed for this fold yet.

Agent findings (1)

literature C 05-01 21:04

Initial digest — ESR1

AlphaFold v6 prediction landed for **ESR1** (Estrogen receptor alpha). UniProt accession: `P03372`. Lane: `sexual_wellbeing`. Mean per-residue pLDDT: **66.43**....